Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Designer drugs"”.
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Abnormal cortical activity leads to misallocation of GABAergic interneurons in the mouse neonatal brain.
… hyödyntämällä erilaisia yhdisteitä sekä Designer Receptors Exclusively Activated by Designer Drugs (DREADD) -teknologiaa. Solulaskenta unilateraalisen sensorisen deprivaation jälkeen paljasti GAD67-positiivisten hermosolujen epätavallisen allokaation korteksin syvimpiin kerroksiin …
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Developing tools to investigate neuronal activity in synaptic pruning /
… AAV8/2-CaMKIIα::hM4Di(Gi)-mCherry-WPRE-hgHp(A) designer receptor exclusively activated by designer drugs (DREADD) to inhibit neuronal activity and visualize inhibited neurons. We determined that this DREADD construct is not suitable to perform morphological analysis of axonal boutons and …
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The External Globus Pallidus: Bidirectional Control Over Anxiety-Related Behavior Mediated By Crfr1
… I show that activation of CRFR1 neurons using Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) increases anxiety-related behavior and movement. I show that anxiety-related behavior and movement are decreased in response to activation of Npas1+ neurons, a class of neuron in …
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Comparison of Liquid-Liquid Extraction and Solid Phase Extraction of Mephedrone
<p>Legal high drugs are modified scheduled drugs. As with any new drug, researchers have to conduct studies to gather information about the drug. The problem with obtaining accurate information on new drugs is that by the time information is gathered, drug abusers and street chemists have developed …
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have gained popularity as a tool to investigate the neural substrates of behaviour in rodents. When used with spontaneous behavioural tests of memory in rodents, DREADDs allow for a unique opportunity to advance our understanding …
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Oligodendrocyte precursor cell states and their regulation
… driving G protein signalling in OPCs using Designer Receptors Exclusively Activated by Designer Drugs modifies their voltage-gated ion channels and glutamate receptors. Collectively, these data suggest that OPCs can transition between electrophysiological profiles in response to …
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Investigation of Glutamatergic Circuitry Underlying Copulatory Reward in Female Syrian Hamsters
… NAc during female sexual behavior, I employed designer receptors exclusively activated by designer drugs (DREADDs) to selectively inhibit these excitatory mPFC efferents. I demonstrated that this selective inhibition decreases sex-induced activation of the NAc, confirming the importance of the …
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The Role of Neuronal Activity in Adult Myelin Plasticity
… plasticity during adulthood was investigated. Designer receptors exclusively activated by designer drugs were used to alter the activity of neurons bidirectionally to observe the activity dependence of myelin. Long-term neuronal activity changes were applied to the optic nerve, a tract in the …
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… neurons and ILC2s, a chemogenetic system using Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) was established using the *Nmu<sup>Cre-iRFP670</sup>* strain. The establishment and study of *Nmu<sup>Cre-iRFP670</sup>* strain has elucidated a significant intestinal neuro-immune …
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Reproducibility of Retention Indices Examining Column Type
… chromatography/mass spectrometry (GC/MS).;When drugs that co-elute (such as methamphetamine and phentermine) are analyzed, a mass spectrum would not be useful as both substances will give similar spectra. This presents problems especially with designer drugs that are similar in structure and …
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Mechanisms of Peripheral Sensitization in Inflammatory Knee Pain
… functional excitatory (Gq) and inhibitory (Gi) designer receptors activated by designer drugs (DREADDs) into knee neurons to bi-directionally control excitability in vitro and that Gi- DREADD activation in vivo can reverse a knee inflammation-induced decrease in digging behavior. Findings from …
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Characterising hippocampal replay in the APP<sup>NL-G-F</sup> mouse model of Alzheimer’s disease
… I used a viral vector to exclusively express Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in medial septal cholinergic neurons of ChAT-cre mice. DREADDs were activated using systemic injection of an actuator (CNO), stimulating cholinergic release in the hippocampus and …
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Marmoset emotional regulation during adolescence and adulthood, with a particular focus on risk-taking and the role of the subgenual anterior cingulate cortex in motivation and affective biases
… on juvenile animals in the lab. DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) are a cutting edge technique that allows for minimally-invasive brain manipulations via a single surgical infusion of viral vectors that induce long-term expression of either an excitatory …
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Stable isotope analysis: a new forensic science tool
… the 1980's the phenomenon of so-called designer drugs was fully recognised in the UK. The prevalence of drugs such as MDMA or 'ecstasy' has increased rapidly in Northern Ireland. In order to establish shipping routes and link batches to countries of production, current analysis of …
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An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding
… activate VTA-projecting PBN neurons using designer receptors exclusively activated by designer drugs (DREADDs). However, we were unable to verify the efficacy of clozapine-N-oxide to activate the circuit and opted for an alternative manipulation. We instead inhibited the VTA with direct …
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
Addictive disorders are a collection of maladaptive behaviors characterized by the uncontrolled use of a rewarding substance. These include substance use disorders, binge eating disorder, certain subtypes of obesity, gambling disorder, and internet gaming disorder. Each of these disorders share …