Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Desacetylierung"”.
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Charakterisierung kernständiger Funktionen der NAD+-abhängigen Deacetylase SIRT2
The human Sirtuin SIRT2 is a deacetylase predominantly found in the cytoplasm during the cell cycle, which co-localizes with the chromatin at the G2/M transition. During this transition SIRT2 was described) to deacetylate lysine-16 of histone 4. Due to the sufficient nuclear export of SIRT2 its …
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Die Regulation der c-MYC-abhängigen Genexpression durch SIRT1 und ASH2
The c-MYC oncoprotein acts as a transcription factor and regulates different aspects of cell behaviour including proliferation, transformation and apoptosis. Deregulated expression of c-MYC is a common feature of many human malignancies and contributes to the transformation of normal to malignant …