Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Dermal fibroblast"”.
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Investigation and control of dermal fibroblast signaling during injury repair
… regulates the injury contraction process in a dermal microtissue on a chip model. We found that a balance of tissue forces generated via RhoA activation is critical for injury contraction, and that spatially localized RhoA activation can recruit new cells to participate in injury contraction. …
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The low-level light therapy affects human dermal fibroblast via TGF-β/smad signaling pathway: in vitro study
… 3 A. Isolation and culture of normal and keloid fibroblasts 3 B. Irradiation 3 C. Determination of the fluence of LLLT 3 D. Cell viability assay 5 E. Real-time polymerase chain reaction (PCR) 5 F. Western blot analysis 5 G. Incubation with exogenous TGF-ß1 6 H. Statistical analysis 6 …
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Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… Current research models use normal human dermal fibroblasts irradiated in vitro to mimic radiation damage, but this is not comparable to ionising radiation and only measures acute changes. Since radiotherapy may induce epigenetic changes leading to alterations in dermal fibroblast …
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Mechanisms of cell senescence: p21 and DNA damage response in aging and longevity
… between centenarians, elderly, young in dermal fibroblast cultures and their response to p21 and DNA damage. Microarray analysis of gene expression in dermal fibroblast cultures of individuals of different ages yielded a tentative "centenarian signature". A subset of genes that were up- …
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Skin cells as a tool in genetic diagnosis of Duchenne muscular dystrophy
… investigated the utility of human autologous epidermal melanocyte and dermal fibroblast cell cultures for use as a tool for genetic confirmation of D/BMD from a much less invasive shave skin biopsy. Methodologies included immunohistochemical, immunocytochemical, Western blot, qPCR analysis and …
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WNT SIGNALING AND HAIR FOLLICLE INITIATION
… Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning remains largely uncharacterized. In my studies, I show that epidermal Wnt …
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The role of fibrolast-derived cytokines on melasma
… and melanocytes. Recently, it was reported that dermal fibroblasts played an important roles on the cutaneous pigmentary disorders. Therefore, we studied the role of fibroblast-derived cytokines on the development of melasma. We collected the specimens of perilesional normal site and lesional …
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The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
… and thinner fibres. The impact of the ageing dermal environment on the hair follicles (HFs) remains unclear. This study documents in situ changes in human female scalp skin of women (19-81 years (yrs)), and corresponding primary cultures of dermal fibroblast (DF) and dermal sheath (DS) cells. …
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Investigation of anthracycline based topoisomerase II inhibitors in triple negative breast cancer
… vascular endothelium cells (HUVEC), and human dermal fibroblast (HFB), compared to free MTX. Meanwhile, UiO-66-MTX exhibited almost similar cytotoxicity as that of free MTX. Although the study emphasizes the potential of KP71 and MOFs as alternative drug delivery platforms for MTX, further work …
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Photo-biomodulation of human skin fibroblast sub-populations: a systematic approach for the optimization of optical treatment parameters
… parameters in photobiomodulation of human skin fibroblasts. The project begins with an extensive analysis of 90 bibliographic reports in photobiomodulation published between 1985 and 2015, and revealed major inconsistencies in optical parameters selected for clinical applications. Seeking …
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Mast Cell Influence in the Progression of Post-burn Hypertrophic Scar Pathophysiology
… postburn scar pathophysiology are constrained to dermal fibroblast activity in the wound and signaling among inflammatory cell populations such as neutrophils, macrophages, and T-lymphocytes. However, mast cells are known to initiate fibroproliferative signaling in other fibrotic pathologies and, …
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Investigation on the Intracellular Sognal Transduction Mechanism of Human Dermal Fibroblasts of Photorejuvenation in Photodynamic Therapy
… on the signal transduction mechanism in human dermal fibroblast and the role of reactive oxygen species (ROS) in vitro. Normal human fibroblasts were treated with various sublethal and relatively low doses of 5-aminolevulinic acid (ALA) and red light. The inhibition of fibroblast proliferation …
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Evaluating the effects of acoustic stimulation on fibroblast cell migration and muscle fibre formation.
… and morphological properties of three different fibroblast cells and muscle cells namely; human lung fibroblast cells (LL24), subcutaneous areolar/adipose mouse fibroblast cells (L929), Human dermal fibroblast cells (HDF) and C2C12P12 muscle cells. Using a speaker-based system, the effects of …
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DEVELOPMENT OF NOVEL COPOLYOXETANES: ANTIMICROBIAL AGENTS
… human red blood cells, HFF (Human Foreskin Fibroblast) and HDF (Human Dermal Fibroblast) was low, indicating good prospects for biocompatibility. Cx-m copolyoxetane antimicrobial efficacy, hemolytic activity and cytotoxicity were further explored by changing quaternary alkyl chain length. …
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Histological Changes in Photorejuvenation Induced by 5-Aminolevulinic Acid Photodynamic Therapy in a Photoaged Mouse Model
… performed. Results: During photoaging, both epidermal thickness and dermal thickness were increased, the amount of dermal collagen fiber was decreased, and the elastotic materials were increased. After ALA-PDT application, both epidermal thickness and dermal thickness were decreased, as the …
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A Novel Antibiofilm Treatment for Surgical Site Infections
… of the DDC- and Cu2+ combination in human dermal fibroblast cells. Antibacterial activity and non-toxicity of Cu(DDC)2 + Cu2+ was also confirmed in vivo in a Galleria mellonella infection model. To enable prolonged exposure of the combination at surgical sites, a depot system was developed …
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Production of Dermal Inspired Collagen Architectures by Lyophilisation and Electrophoretic Deposition
Collagen scaffolds have been used successfully as dermal regeneration templates in clinical applications, but most do not recapitulate the natural tissue structure and are often combined with synthetic membranes to afford additional barrier properties. This work aimed to produce dermal-inspired …
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Electro-mechanically interfacing with biology using piezoelectric polymer nanostructures
… The interaction between PLLA nanotubes and Human Dermal Fibroblast (HDF) cells was also investigated. Cell attachment was found to be significantly higher for nanotubes in comparison to bulk films, and a further increase in attachment was observed between amorphous and crystalline nanotubes. …
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The effect of low level light therapy on wound healing: in vitro study with normal and keloid fibroblast
… (LED) to wound healing, especially in normal dermal fibroblasts and keloid dermal fibroblasts. MATERIAL AND METHODS: Normal fibroblasts and keloid fibroblasts were isolated from human. As preliminary study, we measured the viability of normal and keloid fibroblasts using EZCyTox viability …
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