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Showing 1 to 20 of 177 for “"Derivatization"”.
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Single label fluorescent derivatization of peptides
… as the label of choice and a lower than normal derivatization buffer pH that discriminates against $\varepsilon$-amino derivatization in favor of $\alpha$-amino derivatization provided that this group may act as an efficient nucleophile. A kinetic study was performed in order to identify the …
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On-trap derivatization of short-chain fatty acids
… solid phase microextraction (SPME), and on-fiber derivatization with SPME showed that it is possible to achieve low limits of detection (LODs) for the gas chromatographic (GC) headspace analysis of SCFAs. The goal of this project was to achieve on-trap derivatization of SCFAs by incorporating a …
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EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
Millions of people worldwide have been infected with human immunodeficiency (HIV). Highly active antiretroviral therapy (HAART) has substantially improved the clinical management of HIV-1 infection. Inclusion of HIV protease inhibitors (PIs) in HAART has substantially improved clinical outcomes of …
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DERIVATIZATION OF DIIMINE TRICARBONYL Re(I) COMPLEXES FOR COOPERATIVE CATALYSIS AND SURFACE IMMOBILIZATION
<p>Carbon dioxide (CO2) is a known greenhouse gas and in recent years has been identified as one of the primary contributors to changes in global climate. Nature utilizes CO2 through photosynthesis in which the plants harness energy from the sun to extract electrons from water to convert CO2 into …
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AN INVESTIGATION INTO THE ANALYTICAL UTILITY OF CHANGES IN POLARIZATION ACCOMPANYING ANALYTICAL DERIVATIZATION REACTIONS (FLUORESCENCE)
<p>Derivatization reactions between amines, alcohols and carbonyl groups with various reagents were studied. The goal of the work discussed in this dissertation was to generate basic data to know whether and in what context changes in fluorescence polarization are useful for following analytical …
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Derivatization of porphyrins for DNA and metal ion binding, especially by employing secondary sulfonamide links
<div> <p align="justify"> <font size="3" face="Times">Porphyrins are of exceptional importance in nature, science and technology: For instance, as ligands for metals in supramolecular synthesis, as photosenstizers in photodynamic therapy (PDT), and as building blocks for electronic devices. In …
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Antimycobacterial 2-aminoquinazolinones and benzoxazole-based oximes: synthesis, biological evaluation, physicochemical profiling and supramolecular derivatization
Tuberculosis (TB) is a life-threatening infectious disease caused by Mycobacterium tuberculosis (Mtb). Globally, TB is a major public health burden with an estimated 10.4 million new cases and 1.8 million deaths reported in 2015. Although TB is curable, the treatment options currently available are …
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Exploring hetero-atom derivatization in maltols and flavonols : the effect on reactivity of flavonol dioxygenation.
… and studying the effect of this hetero-atom derivatization on dioxygenation reactivity of free flavonols and metal bound flavonolates. We also explore the effect hetero-atom derivatization has on flavonol and metal-flavonolate nitroxygenation, a reaction analogous to dioxygen wherein O2 is …
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Mass Spectrometric Analysis of Thiol Proteins/Peptides Following Selenamide Derivatization And Electrolytic Reduction of Disulfide Bonds
… a wide range of elution flow rates, online derivatization viareactive DESI to solve the post-column derivatization problems, also integration with EC. In addition, reactive DESI, which exploits the potential for coupling specific ion/molecule reactions with the ionization event, greatly …
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New Derivatization Strategies for Installation of Fixed, Permanent Charges onto Analytes of Biological and Environmental Concern
… from a single biological matrix. Chemical derivatization (CD) reagents can enhance analyte detection and quantification by adding a specific functional group that enhances ionization efficiency and stability. The goal of this project is to design a new CD reagent by synthesizing a Meldrum's …
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A precolumn derivatization procedure for the analysis of marine amino acids with 9-fluorenylmethyl chloroformate and high performance liquid chromatography
… dilabelled products and the pH dependance of the derivatization reaction have been investigated. The reproducibility between-analyses had a percentage error of 2 - 6%. The stability of the derivatives is about 2 weeks at room temperature. The application to physiological samples and seawater has …
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Part One: A Flow Reactor With In-Line Analytics: Design and Implementation Part Two: In-Line Derivatization of Protic Compounds for GC/MS Reaction Monitoring
… to combine a sample preparation step known as derivatization with the reactor-analysis system. Many compounds are not directly amenable to GC/MS analysis, and derivatization is used as a sample preparation step to chemically functionalize compounds so that they can be analyzed with GC/MS. The …
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Organinių alavo junginių mikroekstrakcija ir dujų chromatografinis nustatymas /
… Sodium tetraethylborate has been used for the derivatization. Derivatization conditions (pH, derivatization time, derivatization reagent concentration) have been examined, gas chromatographic-mass spectrometric conditions for derivatized OTC have been optimized. Possibilities to apply three …
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Microextraction and gas chromatographic determination of organotin compounds /
… Sodium tetraethylborate has been used for the derivatization. Derivatization conditions (pH, derivatization time, derivatization reagent concentration) have been examined, gas chromatographic-mass spectrometric conditions for derivatized OTC have been optimized. Possibilities to apply three …
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Trimethylation Enhancement using Diazomethane (TrEnDi) Enhances Mass Spectrometry-Based Analysis of Glufosinate and 3-(Methylphosphinico)propionic Acid in Complex Matrices
… to detect at trace levels. Using the chemical derivatization strategy trimethylation enhancement using diazomethane (TrEnDi), glufosinate and 3-MPPA react with diazomethane and tetrafluoroboric acid to become permethylated, thus reducing their polarity and forming a fixed permanent positive …
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NEW ORGANIC AND HYBRID INORGANIC/ORGANIC LUMINESCENT MATERIALS
… properties, whose discovery fueled further derivatization of the core: in fact, bio-active products, metal complexes and coordination polymers (CP), and phosphorescent organic emitters were synthesized and characterized. My work focused on a further derivatization of the TT scaffold with …
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