Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Depsipeptide"”.
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Synthesis of a cyclic depsipeptide
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characterization of a Novel Dynamic Combinatorial Depsipeptide System with Implications for the Origin of Biopolymers
… in robust dry-heating co-polymerizations to form depsipeptides. These hybrid polymers contain both ester and amide bonds, which each possess dissimilar aqueous lifetimes. We speculated that the relative lability of the ester bond under most aqueous conditions could be harnessed to recycle large …
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Total Synthesis of Himastatin
… relies on expedient preparation of a macrocyclic depsipeptide monomer via hybrid solution/solid phase peptide synthesis, followed by a newly developed oxidative dimerization reaction to secure the C5–C5' biaryl linkage at the center of himastatin’s homodimeric structure. Application of the …
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Total synthesis of N-(benzyloxycarbonyl)didemnin A
Didemnin A, a cyclic depsipeptide isolated from a Caribbean tunicate, was synthesized by coupling two key fragments, (Boc-(3S,4R,5S)-Ist(TBDMS)-(2R,S;4S)-Hip-Leu-Pro-OH (Fragment I)) and (Z- scD-MeLeu-Thr(H-Me$\sb2$Tyr)-OTMSe) (Fragment II). Fragment I was synthesized, in turn, from …
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Total Synthesis of Apratoxin A Analogues
… this natural product is a macrocyclic depsipeptide that contains an unprecedented polyketide domain and a heavily methylated polypeptide domain. The biological mode of action of apratoxin A, to date, has not been fully elucidated. In addition, the mode of action cannot be correlated …
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
… synthesize various lipid tails to install on the depsipeptide globomycin. The natural and non-allo versions of linear globomycin were synthesized and tested using a recently developed fluorescence resonance energy transfer (FRET) assay developed by the Caffrey group.
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Characterizing and Engineering Thioesterases as Biocatalysts for Macrocyclization
… for the chemoenzymatic synthesis of two cyclic depsipeptide NP. Unlike other characterized NRPS TEs, these two demonstrated the ability to catalyze macrolactonization with minimal competing hydrolysis reactivity, making them promising biocatalysts. An uncommon tandem TE domain was also …
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Chemical studies of metabolites from Pacific Ocean marine sponges and the starfish Dermasterias imbricata
… led to the isolation and identification of the depsipeptide majusculamide C (104)which had previously been found in the blue green alga Lyngbya majuscula collected at Enewetak. The synthetic confirmation of the tetrahydroisoquinoline substructure of the starfish metabolite imbricatine (3) was …
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Chemical Synthesis of Novel Calcium-Dependent Lipopeptide Antibiotics
… the side-reactions of diketopiperazine-driven depsipeptide bond cleavage and epimerization upon installation of the dipeptide building block to be addressed. Application of this synthetic strategy towards the native sequence of cadaside B generated the desired peptide albeit in low yield. 1D …
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Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2
… novel antibiotic classes.7 One novel cyclic lipodepsipeptide antibiotic in the clinical pipeline is WAP-8294A2. WAP-8294A2 (Figure 1.0.4) was isolated from the soil bacteria Lysobacter staphylocidin (FERM BP-4900) in Japan in 1997. It is the major component of a mixture of eighteen related …