Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Department of Neurodegenerative Disease"”.
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Molecular genetic characterization of ataxic movement disorders in mouse and human
… in humans. Data presented show the utility of investigating spontaneous mouse mutations in understanding human disease. Through linkage and sequence analysis a novel mutation in the gene encoding inositol 1,4,5-triphosphate receptor type 1 was identified to underlie a severe movement …
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Identification and evaluation of biomarkers for Huntington’s disease
Huntington’s disease (HD) is a devastating, incurable inherited neurodegenerative disorder that commonly affects adults in mid-life. Despite encouraging results from in vitro and animal trials, disease-modifying therapeutic trials in HD are limited by a lack of tools to track disease progression. …
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Assessment and optimisation of MRI measures of atrophy as potential markers of disease progression in multiple sclerosis
There is a need for sensitive measures of disease progression in multiple sclerosis (MS) to monitor treatment effects and understand disease evolution. MRI measures of brain atrophy have been proposed for this purpose. This thesis investigates a number of measurement techniques to assess their …