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Showing 1 to 1 of 1 for “"Deoxyribonucleic acid (DNA) targeting"”.
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Development of enforced stacked intercalators that target trinucleotide repeat mismatches in DNA
… to unstable repeating sequences in genomic DNA. For instance, non-Watson– Crick T–T mismatch base pairs flanked by G–C base pairs appear in myotonic dystrophy type 1 (DM1), which is caused by the expansion of CTG trinucleotide repeats (TNR) in the 3’- untranslated region of the dystrophia …