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Showing 1 to 3 of 3 for “"Deoxynyboquinone"”.
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The development of deoxynyboquinone as a personalized anticancer compound
… toxic by the action of NQO1. We discovered that deoxynyboquinone (DNQ) is a potent cytotoxin through a high-throughput screen, and we designed a concise and flexible synthesis of this molecule which enabled study of its mode of action. We found that DNQ generates toxic levels of reactive oxygen …
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Deoxynyboquinones as NQO1-targeted anticancer compounds and deoxynybomycins as potent and selective antibiotics
Made available in DSpace on 2016-03-02T20:57:24Z (GMT). No. of bitstreams: 5 PARKINSON-DISSERTATION-2015.pdf: 21604741 bytes, checksum: 36ce90169c82a68c9b09739d5545d439 (MD5) LICENSE.txt: 4216 bytes, checksum: 30a9874759f4e96d3a10d148120d7757 (MD5) Parkinson Supplemental 1.pdf: 124148 bytes, …
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Targeting head and neck squamous cell carcinoma through NQO1-mediated cytotoxicity
Head and neck squamous cell carcinomas (HNSCC) are a group of anatomically diverse cancers characterized by their resistance to traditional chemotherapy and radiotherapy modalities. Given that as diagnostic and therapeutic strategies in cancer treatment have seen great improvements over the last …