Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"Dentate gyrus"”.
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Effects of environmental complexity on neurogenesis in the hippocampal dentate gyrus
… Postnatal neurogenesis in the hippocampal dentate gyrus, can be modulated by numerous determinants, such as hormones, transmitters and stress. Among the factors positively interfering with neurogenesis, the complexity of the environment appears to play a particularly striking role. Adult …
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The Human Dentate Gyrus Plays A Necessary Role in Discriminating New Memories
… a rare individual with a specific lesion to the dentate gyrus of his hippocampus who has difficulty distinguishing between studied targets and unstudied lures that are visually similar. In addition, he displays a heightened tendency to recognize studied scenes from degraded pictures. These …
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Functional Correlates of Exposure to Complex, Spatial Environments in Rat Dentate Gyrus
… synaptic transmission was evaluated in the dentate gyrus of hippocampal slices maintained in vitro after rearing rats in relatively complex (EC) or non-complex (IC) environments.
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Tissue injury and remodeling in rat hippocampal dentate gyrus following sodium-potassium-ATPase inhibition.
… a set of fluorescent tags into the hippocampal dentate gyrus. These fluorescent tags, by undergoing fluorescence enhancement upon binding to specific subcellular targets, therefore allow the probing of subcellular dynamics in vivo following inhibition of the Na+, K+-pump. Based on this original …
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Mnemonic Representations of Transient Stimuli and Temporal Sequences in the Rodent Dentate Gyrus In Vitro
… that persistent activity can be evoked in the dentate gyrus. In response to brief stimulation of the perforant path, semilunar granule cells exhibit intrinsic plateau depolarizations driven by NMDAR and L- and T-type voltage-dependent calcium channel conductances, driving persistent synaptic …
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The Role of Injury Mechanism in Neurogenesis Following Repeated Mild Traumatic Brain Injury in the Dentate Gyrus
… neural stem cell (NSC) populations within the dentate gyrus region of the hippocampus become activated. Stem cell differentiation following injury is hypothesized to be unique for diffuse and impact TBIs, primarily due to the differences in mechanotransduction pathways triggered by each …
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Influence of ApoE polymorphism on synaptic morphometry during aging in the dentate gyrus of ApoE knockout and human ApoE transgenic mice
… in the middle molecular layer (MML) of the dentate gyrus of wild type (WT), ApoE knockout (KO) and human ApoE (hApoE) transgenic mice, from 6 to 24 months of age using unbiased stereological methods at the EM level. In hApoE4 mice, there was a 34% decrease in the synapse per neuron ratio …
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Rats selectively-bred for low and high voluntary running: co-selected traits and the effects of voluntary running on the dentate gyrus transcriptome
… running in a mildly stressful environment on the dentate gyrus transcriptome of rats selectively bred for low voluntary running. Emphasis 1 (Chapters 2 and 3) was approached by measuring the performance of LVR and HVR rats in behavioral tests classically designed to measure non-wheel running …
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Stress and Hippocampal Plasticity
<p>The addition of new neurons continues in the dentate gyrus of the adult rat, and this process has been previously shown to be regulated by adrenal steroid hormones, N-methyl-D-aspartate (NMDA) receptor activity, psychosocial stress and learning and memory. Repeated restraint stress is known to …
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Aberrant assembly and function of a hippocampal circuit in a genetic mouse model of schizophrenia
… translocation. Disc1 is highly expressed in the dentate gyrus of the hippocampus of adult mice, a region that is important for learning and memory. Disc1Tm1Kara mutant mice have specific deficits in spatial working memory, a process that requires the interconnectivity of the hippocampus and …
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Tracking The Flow of Information Through The Hippocampal Formation In The Rat
… Pattern separation, hypothesized to occur in the dentate gyrus (DG), refers to the ability to decrease the similarity among incoming information by producing output patterns that overlap less than the inputs. In contrast, pattern completion, hypothesized to occur in the CA3 region, refers to the …
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
… in the subgranular zone (SGZ) of the hippocampal dentate gyrus however, early postnatal development of the dentate gyrus and changes in the neurogenic niche during this time have not been well-studied. Using a well-characterized transgenic mouse that labels early neural progenitor cells with green …
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Engrams, Neurogenesis, and Forgetting
… infantile forgetting can be overcome via a dentate gyrus engram ‘tag-and-activate’ strategy. Optogenetic stimulation of dentate gyrus encoding neural ensembles recovered ‘lost’ infant memories even 90 days following the initial learning event. In a process akin to pattern completion, memory …
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Using Multimodal MRI Techniques to Understand the Role of Hippocampus in Schizophrenia
… (SZ), reduced glutamate signaling in dentate gyrus could lower the LTP threshold in its target region CA3, thus generates increased associative function in CA3, resulting in memories with psychotic content. The loss of mnemonic functions in dentate gyrus could decrease its pattern …
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Effects of Regional Deletion of Rab3A-interacting Molecule and PTEN on Brain Function
… was used to eliminate RIM1 from the hippocampal dentate gyrus and area CA3, while adeno-associated virus expressing PTEN-directed interference RNA was injected into the basolateral amygdala to knockdown PTEN in local pyramidal neurons. In the case of RIM1, I hypothesized that deletion of RIM1 …
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Molecular mechanisms of neuronal homoeostasis in vivo
… (AAV) does not cause any adverse effects in the dentate gyrus nor the CA1 of the mouse hippocampus. I go on to use slice patch clamp methods to measure the change in electrical properties of granule cells in the dentate gyrus and pyramidal cells in CA1 caused by expression of Kir2.1. I show that …
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The differential effects of short-term physical exercise, environmental enrichment and their combination, and short- and long-term environmental enrichment on behavior and associated molecular changes in the brain of C57BL/6 mice
… genes, microglial and astrocyte numbers in the dentate gyrus, and T cell subsets in the cervical lymph nodes were also analyzed. Results: We found that short-term EE reversed the adverse effects of age on cognitive- and anxiety-like behaviors at 14 months. Conversely, short-term PE was found to …
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NOVEL DOPAMINERGIC SIGNALING MODULATING HIPPOCAMPAL SYNAPTIC TRANSMISSION
… transmission in perforant path synapses onto dentate gyrus granule cells and whether such effects differ from those at area CA1 synapses. I found that SKF38393 produced a concentration-dependent increase in field excitatory postsynaptic potential (fEPSP) in both subregions, but that higher …
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