Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Dense-Core Vesicles"”.
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Dense Core Vesicle Heterogeneity in Anterior Pituitary Cells
<p>Peptides, which are packaged in dense core vesicles, are an integral part of the function of the endocrine and neurological systems. The dense core vesicles function as an efficient form of peptide storage prior to regulated exocytosis. Two different dense core specific transmembrane proteins …
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Nature of Large Vesicle Exocytosis in Pancreatic β-cells: Release of ATP and GABA
… were attributable to the exocytosis of large dense core vesicles in these cells and its selective release was regulated by the size of the fusion pore. The combination of the cell capacitance measurements, the electrical measurements of ATP release and amperometric detection of 5-HT release …
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Assessing Crosstalk Between Calcium and cAMP in Pancreatic Alpha Cells
… messenger cyclic AMP. Exocytosis of dense core vesicles containing glucagon ultimately requires an increase in cytosolic calcium. This study focused on the link between cyclic AMP and calcium in pancreatic alpha cells which allows alpha cell regulation. Interactions between calcium …
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Sorting of Cargo Proteins Within the Regulated Secretory Pathway: the Peripheral Membrane Protein HID-1 as a Sorting and Vesicle Biogenesis Factor
<p>Large dense core vesicles (LDCVs) form at the trans-Golgi network (TGN) and mediate the regulated release of neuropeptides and peptide hormones. Despite their central role to physiology, the mechanisms controlling biogenesis and sorting to LDCVs is not well understood. Optimizing the retention …
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Characterisation of new regulators and neural plasticity of the O2-sensing circuit in Caenorhabditis elegans
… in URX and RMG, but show increased secretion of dense-core vesicles from ADL, which could be rescued cell specifically for at least one mutant. Furthermore, we demonstrate that this increased neurosecretion is likely to results from sensitisation of ADL neurons to incoming activity from the …
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Transplantation of the Mammalian Pineal Gland: Studies of Survival, Revascularization, Reinnervation and Recovery of Function
… type was neurosecretory-like (Golgi apparatus--dense-core vesicles) and the second was ependymal-like (rough endoplasmic reticulum--vacuoles containing flocculent material).</p> <p>Pineal grafts were well vascularized by fenestrated capillaries surrounded by consistently wide perivascular …
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Neuropeptidomics: MS-base peptide identification and quantitation study
… into and eventually released from the large dense-core vesicles in a regulated secretory pathway. Neuropeptidomics is inherently challenging because neuropeptides are spatially, temporally and chemically heterogeneous in the brain. In addition, the unconventional peptide precursor cleavages …
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Mechanisms of dendritic peptide release
… for peptide release. One theory is that vesicles stored in dendrites are non-released vesicles ready for recycling or degradation. Immunofluorescent labelling was performed on hypothalamic slices of the transgenic rat where enhanced green fluorescent protein (eGFP) was tagged to …
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Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons
… in discrete puncta reminiscent of trafficking vesicles. Furthermore, Gbb-HA and Cmpy-Venus both colocalize with a marker for dense core vesicles (DCVs) of the regulated secretory pathway (RSP) at the NMJ and in individual puncta within motor nerves, which indicated that Gbb is secreted from …
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Real time course of transmitter release of SSVs and LDCVs; SNARE function analysed in synaptobrevin2 and cellubrevin knock out mice
… Transmitterfreisetzung von SSVs (small synaptic vesicles) und LDCVs (large dense core vesicles) zu berechnen. Dies erfolgte unter Verwendung von Dextran-Molekülen (40000 Da), die den Diffusionskoeffizienten verändern. Der reale Zeitverlauf (Hwreal) der Transmitterfreisetzung aus SSVs liegt bei …
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Analyzing peptide release using mass spectrometry
… to bioactive peptides made in neuron, stored in vesicles, and released into the extracellular space. While many peptides can be detected in a tissue homogenate, these will include processing intermediates and even protein degradation products. It is of great interest in the field of peptidomics …