Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Dense granules"”.
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Platelet Dense Granules Mature Within Late Stages Of Megakaryocyte Differentiation By Cargo Delivery
Platelet dense granules (DGs) are storage organelles for calcium ions, small organic molecules such as ADP and serotonin, and larger polyphosphates that are secreted upon platelet stimulation to enhance platelet activation, adhesion, and stabilization at sites of vascular damage. However, the …
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The influence of mine waste contamination on invertebrates and fish in the Methow River Valley, Okanogan County, Washington (U.S.A.)
… nuclear apoptosis and the formation of electron-dense granules in the matrix of gut epithelial cell mitochondria, (3) whether in situ exposure of caddisfly larvae and triploid trout to Cu and As in water or sediments in the Methow River induces the formation of nuclear apoptosis and …
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Towards the understanding of pericentriolar satellite biology
Pericentriolar satellites (PS) are electron dense granules surrounding the centrosome, the major microtubule-organizing centre in eukaryotic cells. In cycling cells the centrosome promotes spindle assembly and the faithful execution of mitosis. In non-cycling cells it is involved in forming the …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… is a weak platelet agonist stored in platelet dense granules and is released upon platelet activation. ADP activates platelets through two purinergic receptors namely P2Y1 and P2Y12 these receptors couple to Gq and Gi class of G-proteins, respectively. P2Y1 causes calcium mobilization through …
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Rodent inflammasome activation by Toxoplasma gondii
… secretory organelles known as rhoptries and dense granules. Here, we report that Toxoplasma activates the inflammasomes in mice and rats. The inflammasomes are a set of cytoplasmic pattern recognition receptors (PRRs). Activation of the inflammasomes results in caspase-1 activation and the …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… inhibition of the release of ATP from dense granules, anticoagulant, cyclooxgensase (COX-2) activity inhibition, and iron chelating activities. BAA also significiantly stimulates SOD and CAT activity. In addition to the efficacy, the weak cytotoxicity of triterpenoids indicated their …
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Adiponectin : a novel circulating anti-thrombotic factor in humans?
… P2Y1. Since the secretion of ADP from platelet dense-granules is driven by protein kinase C (PKC), we examined the role of PKC in gAd-mediated platelet aggregation. Ablation of PKC using a general inhibitor reduced platelet aggregation and abolished dense-granule secretion stimulated by gAd. …
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Mechanisms of polyphosphate degradation
… for example, store polyP of 60-100mer in dense granules (a type of acidocalcisome); upon activation, platelets release the procoagulant molecule into blood. Once in blood, polyP presumably decays. Previous studies indicated that polyP incubated in human serum has a half-life of about 90 …
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Pathogenic and antigenic characterization of <I>Neospora hughesi</I>
… and deduced amino acid sequences of the dense granule proteins GRA6 and GRA7 of <I>N. hughesi and N. caninum</I>. The newly defined proteins of <I>N. hughesi</I> are referred to as NhGRA6 and NhGRA7. From analysis of the sequences we found that there is a 14.8% difference in deduced amino …
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Polyphosphate is a novel modulator of coagulation and inflammation and is a therapeutic target
… The discovery that polyP is stored in platelet dense granules and is secreted during platelet activation has resulted in a recent burst of interest in the role of this ancient molecule in human biology; however, many standard biochemical techniques are not amenable to working with an inorganic …
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The Regulation of Phosphorylation Events in Platelets
… as well as constituents released from dense granules such as ADP, and serotonin, play an essential role in potentiating the platelet response through activation of other surface receptor mediated pathways. Importantly, downstream of all these separate pathways, kinases become activated …