Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Dense collagen"”.
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Dense Collagen Materials and the Modulation of Fibrillogenesis for Tissue Engineering
… This thesis presents a platform of densified collagen scaffolds that bridges the gap between synthetic materials and living tissue. A scalable, material-based absorptive-deformation process removes interstitial water from neutralised type I collagen in a single step, concentrating the matrix …
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Fibulin-2 Stabilizes Tumor Extracellular Matrix and Drives Malignant Progression of Lung Adenocarcinoma
… were marked by disorganized basement membranes, dense collagen networks, and increased tissue stiffness. Metastasis-prone lung adenocarcinoma cells secreted fibulin-2 (Fbln2), a matrix glycoprotein involved in ECM supra-molecular assembly. Fibulin-2 depletion in tumor cells decreased the …
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An In Vitro 3D Model to Evaluate Behaviour of Breast Cancer Cells and Response to Treatment
… cancer masses' (ACM) by embedding cells in a dense collagen type-I. The ACMs were maintained under flow (150 μL/min) and flow/pressure (550 μL/min, ~19 mmHg) conditions. A significant reduction in cell viability was observed when cancer cells were grown as ACM compared to 2D culture. Cell …
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Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth
… extravascular regions of the tumor due to the dense collagen matrix, resulting in heterogeneous therapeutic effects and likely contributing to tumor regression and development of resistance. We propose a multistage nanoparticle system that "shrinks" when it extravasates into the tumor and is …
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Engineering Tumor-Targeting Bacteria and Characterizing Their Interactions with Tumor Cells in Therapy-Resistant Breast Cancers
… severe dose-limiting toxicities. Moreover, the dense collagen-rich extracellular matrix (ECM) of solid tumors restricts intratumoral drug transport, motivating strategies that function across BC subtypes, overcome ECM barriers, and inform lowered clinical dosing. Bacteria-based cancer therapy …
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Capillary characteristics in microfluidic experiments and computational simulation
… microvascular endothelial cells in 2.5 mg/ml dense collagen I gel and by using media supplemented with 40 ng/ml VEGF and 500 ng/ml Ang 1 for two days. It has been shown in many studies that VEGF acts as an angiogenic factor and Ang 1 acts as stabilizing factor. Here we showed that their roles …