Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Dendritic spines"”.
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Morphological Study of Dendritic Spines
… the neuron structure and the characterisation of dendritic spines is nowadays a hot topic in neurobiology research. Dendrites are cellular structures whose main objective is to conduct the electrochemical stimulation received from other neural cells to the cell body of the neuron from which the …
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Functional and ultrastructural investigation of mouse and human dendritic spines
Dendritic spines are the physical site of the majority of excitatory synaptic connections in the mammalian brain. Their complex morphological attributes and protein composition have inspired decades of theoretical and experimental work on how classes of dendritic spines differentially sculpt input …
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Spatiotemporal Dynamics of CaMKI During Structural Plasticity of Single Dendritic Spines
… lifetime imaging, while inducing LTP in single dendritic spines of rat (Rattus Norvegicus, strain Sprague Dawley) hippocampal CA1 pyramidal neurons using 2-photon glutamate uncaging. Using RNA-interference and pharmacological means, we also characterize the role of CaMKI during spine structural …
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
Dendritic spines are the main sites of synaptic input onto excitatory neurons. As recent experiments showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a …
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The Protective Effects of Memantine On The Morphology and Activity of Irradiated Dendritic Spines
… </strong></p> <p><strong>Activity of Irradiated Dendritic Spines</strong><strong></strong></p> <p>Thanh T. Lam, M.S.</p> <p>Advisory Professor: David R. Grosshans, M.D, Ph.D.</p> <p>Although radiotherapy is an effective treatment for brain tumors, the adverse effects of such treatments may result …
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Morphological characterization of medium spiny neuron development in vitro
… MSN that changes in all of these diseases is the dendritic spine, a sub-micron protrusion responsible for receiving excitatory (glutamatergic) signals. Dendritic spines undergo structural and functional changes during development, normal aging, and disease. To date, no studies have specifically …
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FMRP dependent synaptic delivery of messenger RNA
… facilitate mRNA deceleration and localization in dendritic spines upon neurotransmitter stimulation. Consistent with these findings, local protein synthesis was also enhanced in dendritic spines after stimulation. These results suggested that FMRP could mediate synaptic mRNA delivery for local …
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Structural dynamics and synaptic development in the visual system
… study details the developmental properties of dendritic spines, the principle sites of excitatory synaptic contacts, during a period of synaptogenesis in the developing mouse cortex. The second study extends these findings and examines the properties of dendritic spines during a period of …
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Ultrastructure and morphometric analysis of hippocampal synapses in the Fmr1-/y mouse model of fragile X syndrome
… dependent translational regulator at the base of dendritic spines. In an attempt to understand its role, dendritic spines in the dentate gyrus (DG) and cornu ammonis 1 (CA1) hippocampal regions of three-week old Fmr1- mice were analyzed and compared to wildtype (WT) littermate controls using …
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Effetto della separazione materna sulla plasticità dei neuroni nell’ippocampo delle mamme e della prole
… and we analized density and morphology of dendritic spines and arborization of the dendritic tree in granule cells of hippocampus. Another goal of our study is to verify on the offspring, if stress induced by insufficient maternal care in the first 15 days of life increases the …
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Optimization-Based Methods for Reconstruction and Structural Quantification of Neurons and Glia from Microscopic Images
… the detailed tripartite structures formed by dendritic spines, axon terminals, and astrocyte processes, which are crucial for understanding and predicting the functions of neural circuits. However, most methods for segmenting dendritic spines from electron microscopy images focus solely on …
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Developing tools to investigate neuronal activity in synaptic pruning /
… morphological analysis of axonal boutons and dendritic spines but could be used with other neuron visualization tools. Finally, we proposed a strategy to analyze morphology of axonal boutons and dendritic spines of neurons inhibited during peak of synaptic pruning utilizing co-localization of …
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A Three-Molecule Model of Structural Plasticity: the Role of the Rho family GTPases in Local Biochemical Computation in Dendrites
… effort has been directed towards the study of dendritic spines, small protrusions emanating from neuronal dendrites that constitute the majority of recipient sites of excitatory neuronal connections. The unique, mushroom-like morphology of these tiny structures has earned them considerable …
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Dendritic Spine Density Varies Between Unisensory and Multisensory Cortical Regions
In the brain, the dendritic spine is a point of information exchange that extends the neuronal surface on which synapses occur, as well as facilitates and stabilizes those contacts. Furthermore, dendritic spines dynamically change in shape and number in response to a variety of factors. Dendritic …
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Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo
… relative influence on excitation in specific dendritic segments, and ultimately regulate neuronal firing. However, the structural dynamics of excitatory and inhibitory synapses in vivo, and their relation to each other, is not well understood. To gain insight into synaptic remodeling in the …
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Development of the multi-scale dynamic modeling techniques for multi-modal brain recordings
… connectivity. It has been demonstrated that dendritic spines increase or become bigger after long-term potentiation while decrease or become smaller after long-term depression. Thus, we hypothesized the existence of excitatory and inhibitory connectivity can be revealed by the dynamics of …
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Effects of Neuronal Nogo-A on Properties of Excitatory Synapses of the Sensorimotor Cortex
… NogoA influences the density and morphology of dendritic spines in the developing CNS, in part, by regulating the maturation and stability of glutamatergic synaptic input. To examine the roles of Nogo-A at the excitatory synapse of the neocortex, we used RNAi directed against Nogo-A and …
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Linking WRP/srGAP3 to the Cognitive Deficits in 3p- Syndrome and Its Role in the Regulation of Dendritic Filopodia Formation
… IF-BAR domain. WRP localizes to the membranes of dendritic shafts via its IF-BAR domain where it is enriched in filopodia like projections. During dendritic filopodia formation, WRP functions to regulate the WAVE-1 complex and its downstream effectors, including the Arp2/3 complex. Loss of WRP in …
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Rescue of Fragile X Syndrome phenotypes in Fmr1 KO mice by the small molecule PAK inhibitor FRAX486
… abnormalities in the density and morphology of dendritic spines - the sites of connections between neurons and critical substrates for learning. Abnormal dendritic spines is a common feature in FXS, idiopathic autism, and intellectual disability. Thus, this neuroanatomical abnormality may …
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MOLECULAR MECHANISMS REGULATING SPINE REMODELLING
… for activity-dependent synaptic plasticity and dendritic spine remodeling. Recent studies have shown that N-Cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that modulating ADAM10 localization and activity at synaptic sites regulates its processing of N-Cadherin. This …
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