Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Dendritic spine"”.
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Dendritic Spine Density Varies Between Unisensory and Multisensory Cortical Regions
In the brain, the dendritic spine is a point of information exchange that extends the neuronal surface on which synapses occur, as well as facilitates and stabilizes those contacts. Furthermore, dendritic spines dynamically change in shape and number in response to a variety of factors. Dendritic …
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… an important class of molecules controlling dendritic spine plasticity. Although they are typically described as cytoskeletal modulators, roles for the GTPases in endocytosis and cell polarity establishment have also been defined. The neuronal proteins a1- and a2-chimaerins belong to a group …
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Effect of chemically induced mGluR-dependent long-term depression on dendritic spine volume
… engrams are formed at synapses throughout the dendritic arbor. However, the Clustered Plasticity Hypothesis suggests that neurons store long-term memory engrams at synapses that tend to be spatially clustered within dendritic branches, as opposed to dispersed throughout the dendritic arbor. …
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When good synapses go bad: dendritic spine dysgenesis in a mouse model of Fragile X mental retardation
… well-studied and interesting is a pattern of dendritic spine “dysgenesis”, found in patients and animal models of the disorder. Specifically, dendritic spines, thorn-like protrusions associated with synapses, appear “immature”: often exhibiting abnormal length and shape, and found in higher …
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A role for the SHANK1 scaffold protein in experience-induced synaptic plasticity and memory consolidation
… Specifically, numerous studies have suggested dendritic spine plasticity across development and during learning as a likely process for memory consolidation. During early postnatal development, dendritic spine density increases in numerous sensory cortices, reaching a peak in adolescence, …
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The presence of naked purkinje cell dendritic spine specializations and other pathological changes in ten day saline and methylazoxymethanol-injected Swiss albino mice
Thesis (M.S.)--Michigan State University. Dept. of Anatomy, 1976
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MOLECULAR MECHANISMS REGULATING SPINE REMODELLING
… for activity-dependent synaptic plasticity and dendritic spine remodeling. Recent studies have shown that N-Cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that modulating ADAM10 localization and activity at synaptic sites regulates its processing of N-Cadherin. This …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… GTPases and subsequent F-actin remodeling and dendritic spine structural dynamics. I report that Vav-family GEFs are activated by BDNF/TrkB signaling, and are required for BDNF-induced Rac-GTP formation. Vav GEFs, which are enriched at hippocampal glutamatergic synapses, are necessary for rapid …
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Morphological characterization of medium spiny neuron development in vitro
… MSN that changes in all of these diseases is the dendritic spine, a sub-micron protrusion responsible for receiving excitatory (glutamatergic) signals. Dendritic spines undergo structural and functional changes during development, normal aging, and disease. To date, no studies have specifically …
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The rule of Myosin II and Rap2 in synaptic structure and function
… are Hebbian plasticity and changes in dendritic spine morphology. Recent proteomics studies have uncovered many proteins that reside in the synapse and could play critical roles in these processes. Among these are the molecular motor myosin II and the Ras family GTPase Rap2. Myosin II …
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The Role of Nogo-A in Memory and Neuronal Plasticity in the Aged Rodent Brain
… intact pathways to denervated areas, as well as dendritic sprouting and increased dendritic spine density in the contralateral sensorimotor cortex. In the present project we aimed to investigate whether anti-Nogo-A immunotherapy improves performance on a spatial memory task after a sensorimotor …
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Synaptic morphology, function, and regulation in a paediatric-onset neurodegenerative disorder
… of changes in the morphology and number of dendritic spines on layer 5 pyramidal neurons in the cerebral motor cortex. 2. Elucidate the biological impact of synaptic dysfunction on neuronal activity by electrophysiology. 3. Determine the underlying mechanisms contributing to dendritic spine …
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Critical window in autism : a study on Shank3
… a novel neuronal tracing technique to study the dendritic spine density, and found that the dendritic spine number is also significantly increased in the rescue condition after development. In addition, we show that while anxiety and motor coordination are not improved, social interaction and …
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An investigation into the role of cannabinoid and group 1 metabotropic glutamate receptors in the control of rhythmic locomotion in hatchling Xenopus Laevis
… in the morphology of neurons, particularly the dendritic spines dimension and membrane viscoelasticity. To do this, a primary X. laevis neuron-muscle co-culture was developed from the literature. The cultures were treated with the same pharmacological treatments and fixed in glutaraldehyde 5%. …
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The role of Polo-like kinase 2 in synaptic function and plasticity
… during elevated activity resulted in increased dendritic spine size and density as well as a "run-up" in synaptic strength that prevented subsequent LTP. Thus, the homeostatic functions of Plk2 allow synapses to remain within a modifiable range during prolonged heightened network activity. In …
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The Role of DNA Methylation in Addiction and Depression
… that chronic cocaine selectively increases thin dendritic spines on NAc neurons and that DNA methylation is both necessary and sufficient to mediate these effects. I then used complementary genome wide techniques aimed at identifying cocaine-induced DNA methylation at gene targets. …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
… including lower parvalbumin labeling and lower dendritic spine density, features similar to those observed in human condition. GluN2C heterozygous and knockout mice also exhibit behavioral and cognitive deficits relevant to schizophrenia. Moreover, a GluN2C/GluN2D potentiator, CIQ, attenuated …
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Airway dimensions in the sudden infant death syndrome
… intrathoracic petechial haemorrhage, delayed dendritic spine maturation and delayed myelination of regions of the central nervous system and vagus nerves. The peak incidence of SIDS occurs between 6 to 11 weeks of life with 90% of SIDS deaths occurring by 6 months of age. Death is usually …
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Investigating protrudin’s role in neuroprotection and axon regeneration in the central nervous system
… It also does not have any substantial effect on dendritic spine morphology, so it does not indiscriminately promote cellular outgrowth. On the other hand, protrudin does interact with ER export and associated secretory machinery. Overexpression of an active mutant of protrudin increases the …
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Morphological Study of Dendritic Spines
… the neuron structure and the characterisation of dendritic spines is nowadays a hot topic in neurobiology research. Dendrites are cellular structures whose main objective is to conduct the electrochemical stimulation received from other neural cells to the cell body of the neuron from which the …
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