Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 415 for “"Dendritic cells"”.
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Visualizing Dendritic Cells In Vivo
… living lymphoid tissue the physiological role of dendritic cells in tolerance and immunity; this was achieved by intravital microscopy of fluorescently-labeled DCs and lymphocytes in the inguinal lymph nodes. We generated mice that specifically expressed EYFP in their dendritic cells and observed …
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Plasmacytoid dendritic cells & immunotherapy of cancer
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Experimental brain tumors, dendritic cells and immunotherapy
… The aim of this study was to develop a dendritic cell (DC)-based vaccine for the treatment of experimental brain tumors with the future prospect of translating this treatment into the clinical application. We first demonstrated that the N29 and N32 rat brain tumors closely resemble human …
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Engineering dendritic cells for enhanced cancer immunotherapy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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THE ROLE OF DENDRITIC CELLS IN GRAFT REJECTION
… of costimulatory molecules and TLRs in Dendritic Cells (DCs), as a key to the mechanisms underlying the barrier to tolerance induction. Dendritic cells are the sentinels of the immune system. Immature Dendritic cells, which are characterized by low MHC Class II expression and weak T cell …
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Dendritic Cells in Normal and Inflamed Human Skin
… immune system, particularly effector CD8+ T cells infiltrating the epidermis. Recent studies, however, show that inhibitors of tumor necrosis factor (TNF) are also effective therapeutics. Activated dendritic cells (DCs) produce large ammounts of TNF which acts in an autocrine loop to increase …
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The ontogeny and function of intestinal dendritic cells
… diseases (IBD) and food allergies. Conventional dendritic cells (cDCs) are key regulators of adaptive immune responses. cDCs are found throughout the intestinal lamina propria and in gut associated lymphoid tissues (GALT) of mice and humans. Intestinal cDCs migrate constitutively to mesenteric …
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Phenotype and function of intestinal CD103+ dendritic cells
… immune responses to pathogens. Intestinal dendritic cells (DCs) and macrophages, found throughout the villous lamina propria and intestinal lymphoid tissue in both mice and humans are thought to play key roles in this process. DCs at these sites constantly sample and process both luminal …
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Regulation of type I interferons in murine dendritic cells
Conventional Dendritic cells (cDCs), a specialized group of immunological sentinels with tree-like or dendritic shapes, are critical for recognition of danger signals, presentation of antigens and control of a spectrum of innate and adaptive immune responses. Type I interferons (IFNs), as important …
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The Role and Regulation of Id2 In Dendritic Cells
<p>Dendritic cells (DCs) are specialized innate immune cells that sense pathogen-associated signals via pattern recognition receptors, including the TLRs, and subsequently stimulate adaptive immune responses to combat infection. The mutual antagonists and transcriptional regulators inhibitor of DNA …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… of the Aryl hydrocarbon receptor (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. We evaluated the consequences of AhR …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… of the Aryl hydrocarbon receptor (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. We evaluated the consequences of AhR …
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FAMIN in dendritic cells biochemically restrains T cell priming
… protected against influenza A infection, with dendritic cell (DC)- dependent excessive activation of CD8<sup>+</sup> T cell responses in their FAMIN-deficient counterparts. Loss of FAMIN activity in DCs was shown to result in increased priming of both CD4<sup>+</sup> and CD8<sup>+</sup> T cells …
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Characterization of Dendritic Cells in the Bovine Mammary Gland
… mastitis pathogens could potentially target dendritic cells (DC). While there has been some research describing bovine DC populations in-vitro, little is known about DC in mammary tissue. In this study, immunohistofluorescence was used to identify and localize bovine mammary DC. DC were found …
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Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
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The Biology of Dendritic Cells in the Context of Autoimmunity
… is poorly understood. Because plasmacytoid dendritic cells (pDCs) are the primary type I IFN producers, their role in SLE has long been suspected, with murine pDC depletion models successfully delaying the progression of murine lupus-like disease. However, the mechanism behind how exactly …
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Investigation of dendritic cells as a vector for vaccine delivery
Dendritic cells (DC) are an attractive target for both vaccine targeting and use as a delivery vehicle due to their ability to direct innate and adaptive immune responses. In this study a procedure was developed where DC were employed as a vehicle to induce cell-mediated immune responses to the …
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Role of dendritic cells in response to cytokine gene adjuvants
… in outbred species requires optimisation. Dendritic cells (DC) are unique in that they are the only cells capable of stimulating naive T cells, the major requirement of successful vaccination. Lack of efficacy of DNA vaccines may be due to inefficient targeting of DC. One strategy to …
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Reprogramming the immune environment in breast cancer via dendritic cells.
… Here we show that human breast cancer cells produce thymic stromal lymphopoietin (TSLP). Breast tumor supernatants, in a manner dependent on TSLP, induce expression of OX40L on dendritic cells (DCs). OX40L⁺ DCs are found in primary breast tumor infiltrates. OX40L⁺ DCs drive development …
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