Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 175 for “"Dendritic cell"”.
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… is characterized by the breakdown of B cell immune tolerance to self-antigens and consequent production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus …
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Computational Methods for Investigating Dendritic Cell Biology
… response results from the interplay of two cellular systems: the innate immunity and the adaptive immunity. In the past decades, dendritic cells have emerged as major players in the modulation of the immune response, being one of the primary links between these two branches of the immune …
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Dendritic cell regulation of immunity to Leishmania donovani
Dendritic cells lie at the interface of innate and adaptive immunity, critically contributing to the generation of an antigen-specific immune response. Although the mechanisms by which they initiate protective immunity are well characterised, their precise contribution to the subsequent regulation …
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Astrocytes modulate microglial phenotype and dendritic cell-like properties
Microglia are the resident immune cells of the CNS. In the healthy CNS, they express negligible levels of MHC II molecules as well as co-stimulatory molecules CD40, CD80 and CD86 necessary for antigen presentation to and activation of T cells. Co-stimulatory molecule expression can be induced in …
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Regulation of Dendritic cell function by the ocular microenvironment
… in animal models of antigen presenting cell function. My hypothesis was that in humans the normal ocular microenvironment maintains an immature dendritic cell (DC) phenotype, whereas in intraocular inflammation (uveitis) this regulation fails, permitting full DC maturation leading to the …
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Innate Immune Responses in the Alternaria-Dendritic Cell Interaction
… rhinitis, asthma, and chronic rhinosinusitis. Dendritic cells are known as the type of antigen presenting cells most often associated with allergic inflammation. In this study, we used mouse bone marrow-derived dendritic cells (BMDCs) as a model to study the ability of A. alternata spores and …
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The Dendritic Cell Response to Exogenous and Endogenous Danger Signals
… trigger, 2) cytokine dysregulation in immune cells, and 3) the treatment of end organ damage in the form of lupus nephritis. Viral infections have long been associated with the development of systemic autoimmune disease, but the mechanisms by which chronic bacterial infections may promote …
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Pattern Recognition Receptors & Dendritic Cell Function in health and disease.
Contains fulltext : 71516.pdf (Publisher’s version ) (Open Access)
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
Dendritic cells (DCs) are potent initiators of the adaptive immune response. Their trafficking from sites of inflammation to lymphoid tissue is essential to their function. Exactly how dendritic cells integrate multiple chemotactic cues to organize an accurate migratory path is not fully …
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Dendritic cell dysfunction restrains cytotoxic T cell responses against cancer
… are often characterized by the presence of a T cell infiltrate in tumors. However, T cell infiltration does not always correspond to ICB efficacy. Tumor-reactive T cells can acquire persistent dysfunctional states, which are resistant to ICB reinvigoration. Increasing evidence suggests that T …
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Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
… affected but previously published data suggest dendritic cells (DC) largely escape this phenomenon. DC have three main functions: upregulation of cell surface expression of costimulatory molecules, antigen presentation, and cytokine secretion which lead to activation of T cells. The milieu of …
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Dendritic Cell Regulation of Peripheral Tolerance in Polyclonal T Cell Repertoires
<p>Dendritic cells (DCs) play a pivotal role in determining whether the outcome of the immune system's encounter with antigen will be immunity or tolerance. Using an antibody against the DEC-205 receptor, antigens have been delivered specifically to DCs in vivo. Under steady state conditions, such …
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Treatment of Systemic Lupus Erythematosus by Nutrition and Dendritic Cell Targeting
… MRL/lpr mice, tRA administration reduced immune cell numbers in the secondary lymphoid organs and improved glomerulonephritis. However, circulating autoantibodies and inflammation in renal tubulointerstitium and other organs were increased. The detrimental effects of tRA were not present in MRL …
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A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… the phagocyte lineages are a very heterogeneous cell compartment with specialized functions in innate immunity and induction of adaptive immune responses. Their generation from a common precursor must be tightly controlled. Interference within lineage formation programs for example by mutation or …
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Bidirectional Natural Killer Cell and Dendritic Cell Interactions in HIV-1 Pathogenesis
Natural killer (NK) and dendritic cell (DC) interactions are pivotal for the development of immune responses, which lead to bidirectional NK:DC activation. In HIV-1 infection, both NK cell and DC function are impaired, resulting in dysfunctional NK:DC crosstalk. We demonstrate that NK:DC …
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Targeting of specific developmental pathways to understand dendritic cell heterogeneity and function
Dendritic cells (DC) are cells of the immune system that are specialized in sensing and responding to pathogens. They coordinate innate and adaptive immune responses to different types of pathogens through the release of inflammatory cytokines, secretion of interferon, and presentation of antigen …
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Engineered Type 1 Conventional Dendritic Cell–Based Therapies for In Situ Cancer Immunization
… outcomes and limits patient’s treatment options. Dendritic cells (DCs) are antigen-presenting cells (APCs) and play a critical role in immune modulation and communication with other immune cells, including CD8+ and CD4+ T cells. They internalize, process, present antigens to T cells, express …
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Biomaterials for tissue engineering for rheumatoid arthritis based on controlling dendritic cell phenotype
… this research was to understand the response of dendritic cells (DCs) to different biomaterials upon contact and identify biomaterials suitable for use in tissue engineering constructs for rheumatoid arthritis (RA) applications. Differential levels of functional DC maturation were observed …
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The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function
… mechanism by which these responses are induced. Dendritic cells (DC’s) play a crucial role in linking the innate to adaptive arms of the immune system and directing the subsequent immune responses. Here, we report that Fasciola hepatica tegumental antigens (FhTeg) can suppress DC maturation and …
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