Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Dendritic arborization"”.
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Developmental Nicotine Exposure And Its Effects On Morphology And Electrophysiology Of Hypoglossal Motoneurons In The Neonatal Rat
… significant differences in the complexity of the dendritic arborization, showing that neurons from DNE animals had shorter dendrites that branched less often. We also used computational analysis to gain insight into mechanisms that may underlie the changes in spike-timing precision and …
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THE INTERPLAY BETWEEN HPCAL4 AND MECP2: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PUTATIVE TARGET FOR RETT SYNDROME THERAPY
… development and function including defects in dendritic arborization and spine density. Besides Mecp2, several other genes have been associated with RTT or RTT-like phenotypes and the number of disease-candidate genes has grown over the years. Therefore, identifying novel molecular players may …
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Serotonin Modulates the Maturation of the Medial Prefrontal Cortex and Hippocampus: Relevance to the Etiology of Emotional and Cognitive Behaviors
… (IL) sub-region of the mPFC, displayed decreased dendritic arborization, concomitant with reduced intrinsic excitability. Conversely, prelimbic (PL) layer 2/3 neurons displayed normal dendritic arborization, but increased intrinsic excitability. Together, these changes produce a reduced IL/PL …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… activity-dependent neuronal development such as dendritic arborization, spinogenesis and synaptogenesis are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in …
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Transcriptional control of somatosensory neuron diversification in Drosophila
… are poorly understood. I have used the multidendritic (md) sensory neurons of the Drosophila melanogaster peripheral nervous system to identify genetic and molecular programs that coordinate dendrite and axonal morphogenesis in individual sensory neurons. The homeodomain transcription factor …
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Chronic Stress Effects on Prefrontal Cortical Structure and Function
… medial prefrontal (mPFC) and orbitofrontal (OFC) dendritic morphology underlie impairments in the behaviors that they subserve. Chronic stress induced a selective impairment in attentional control and a corresponding retraction of apical dendritic arbors in mPFC. By contrast, stress did not …
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Changes in the Morphology of Hypoglossal Motor Neurons in the Brainstem of Developing Rats
… with no significant change in shape. However, dendritic arborization increased in extent and complexity with branching of neurons significantly increasing from P1 through P13, with the greatest increase at P10–P13 based on the Sholl method. Three age groups 1) P1–P5, 2) P7–P12, and 3) P13–P21 …
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THE CRAYFISH VISUAL SYSTEM: INTRACELLULAR STUDIES AND MORPHOLOGIES OF IDENTIFIED INTERNEURONS
… Following identification of each cell, the dendritic morphology was observed with lucifer yellow iontophoresis and subsequent fluorescence microscopy. An individual SF possesses a dendritic arborization restricted to that portion of the Medulla corresponding to its corneal receptive field. …
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Development of leg motor neurons in drosophila melanogaster
… leg motor neuron birth orders, axonal and dendritic morphologies by using single cell labeling methods. Each motor neuron that has unique axonal targeting and dendritic architecture is born in a stereotypic birth order from a specific lineage. Leg motor neurons targeting similar muscles …
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Effetto della separazione materna sulla plasticità dei neuroni nell’ippocampo delle mamme e della prole
… and we analized density and morphology of dendritic spines and arborization of the dendritic tree in granule cells of hippocampus. Another goal of our study is to verify on the offspring, if stress induced by insufficient maternal care in the first 15 days of life increases the …
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NEURAL PRECURSOR/STEM CELL-BASED THERAPY: A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF RETT SYNDROME
… neuronal defects such as reduction in soma size, dendritic arborization and synaptic plasticity together with an excitation/inhibition unbalance. Basic and preclinical studies on RTT have largely benefitted from the use of mouse models mutated in Mecp2. Among these, the most studied is the full …
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Layer specific differences in the mouse auditory corticocollicular system
… differences in physiological properties and dendritic arborization between neurons in layer 5 and layer 6 make it likely that each type plays a distinct role in controlling auditory information processing in the midbrain. Very little is currently known about the nature of the inputs from the …
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Imaging genetics evidence for the neurodevelopmental model of schizophrenia
… of reduced density of myelinated axons and dendritic arborization in large-scale cortico-subcortical networks. Cortical, subcortical and white matter micro-structure may therefore be linked to the genetic mechanisms of schizophrenia. Chapter 3 examines the genetic architecture of normative …
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The Role of Nogo-A in Memory and Neuronal Plasticity in the Aged Rodent Brain
… intact pathways to denervated areas, as well as dendritic sprouting and increased dendritic spine density in the contralateral sensorimotor cortex. In the present project we aimed to investigate whether anti-Nogo-A immunotherapy improves performance on a spatial memory task after a sensorimotor …