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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"Dendrimer"”.
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Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
<p>PAMAM dendrimers are a class of well-defined, hyperbranched polymeric nanocarriers that are being investigated for ocular drug and gene delivery. Their favorable properties such as small size, multivalency and water solubility can provide significant opportunities for many biologically unstable …
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Pamam dendrimer-based therapeutic and diagnostic nanodevices
<p>Dendrimers are ideal materials to be used in the emerging field of nanomedicine. Their nanoscale size and high density of functional groups on their peripheries allow them to be used for various biomedical applications. This work exploits dendrimers as drug delivery vehicles and a versatile …
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Octopus and dendrimer molecules with silsesquioxane cores
… materials with pendent groups from a core, and dendrimer molecules, or materials with a defined pattern of branching from a core are means of obtaining molecules of designed architecture. The work presented here involves the synthesis and characterization of octopus and dendrimer molecules of …
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Gene delivery with amphiphilic lower generation polypropylenimine dendrimer
… generation amphiphilic polypropylenimine (PPI) dendrimer with good aqueous solubility was developed and tested as a gene delivery agent. PPI dendrimer generation 3 (DAB-16-Am) was substituted with a low level of cetyl chains (less than 5 molar percent) by reaction with 1-bromohexadecane under …
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Novel sustained release formulation of leveodopa-dendrimer conjugate
… was prepared by conjugating it with PAMAM dendrimer which was further incorporated in a nanoparticle. To prepare the conjugate levodopa (1mg/ml) was added to dendrimer solution (1mg/ml) at alkaline pH. They were allowed to react for 45 minutes with constant stirring and then lyophilized. …
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Fukóz- és galaktóz-kötő lektinek dendrimer típusú ligandumainak szintézise
Kutatásom célja olyan multivalens, L-fukóz- és D-galaktóz-kötő lektinek ligandumainak szintézise, amellyel gátolhatjuk egyes baktériumok lektinjeinek specifikus és reverzibilis kötődését a gazdasejt felszínéhez. Ezen vegyületek a későbbiekben alkalmasak lehetnek terápiásra felhasználásra.
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
… lungs. In this work, we desgined polyamidoamine dendrimer (PAMAM) conjugates which can only release DOX intracellularly, while being stable in physiological environment. We observed the PAMAM-DOX conjugates upon local delivery to the lungs can significantly inhibit tumor growth both in vitro and …
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PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING
… to treat chronic wounds. Comprised of gelatin, dendrimer, synthetic polymer and antibiotics, the dressing was electrospun to mimic the natural extracellular matrix (ECM). Gelatin is biocompatible, biodegradable, non-toxic, and easily available. The antibiotic, doxycycline, has the ability to …
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Synthesis and Activation of Nanoscale Dendrimer-Derived Supported Noble Metal Catalysts
<p>In recent years, PAMAM dendrimers have been used as templates for the preparation of supported metal catalysts. This approach takes advantage of several unique characteristics of these dendrimers such as the ability to complex metal cations in solution and to protect them from aggregation until …
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A dendrimer-based prodrug for use in an anti-cancer nanocell
Cancer science is a heavily researched and rapidly changing field. Cutting edge research consistently reveals unique features of tumors that can be exploited for treatment. For example, it is well known that cells of varying tumor types have unique molecular markers and cell-surface receptors - …
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Development of Dendrimer-based Technologies for Phosphoproteomics and Glycoproteomics in Biomarker Discovery
… by taking advantage of the properties of dendrimers – a soluble nanopolymer with chemically well-defined structure and functional surface groups – to facilitate the detection and quantification of PTMs using several biochemical assays and mass spectrometry-based shotgun proteomics.
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An Investigation of The Use of Dendrimer-Based Carrier to Cross Cellular Barrier
Dendrimers are a novel class of highly branched polymers with a high degree of uniformity and monodispersity. As a result of the unique properties and characteristics of dendrimers, they have found a wide range of pharmaceutical applications. This study investigated the ability of polyamidoamine …
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Re-engineering of Dendrimer-Based Lipid Nanoparticles for Efficient and Precise HDR-Mediated Gene Editing
… This dissertation details the development of dendrimer-based lipid nanoparticles (dLNPs) for the encapsulation and delivery of multiple nucleic acids necessary for HDR: Cas9 mRNA, sgRNA, and a donor DNA template containing the correct nucleic acid sequence, as well as the optimization of …
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Dendrimer Modified Silica Nanoparticles as Fluorescent Chemosensors for the Detection of Copper and Cyanide Ions
… modified with branching polyamidoamine (PAMAM) dendrimers, which function as selective turn-off Cu<sup>2+ </sup>ion chelators and platforms for the attachment of rhodamine isothiocyanate (RITC) or fluorescein isothiocyanate (FITC) fluorescent dyes. In the presence of Cu<sup>2+ </sup>ions, the …
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Design Of Functional Dendrimer Nanocarriers And Their Formulations In Propellant-Based Inhalers For Pulmonary Drug Delivery
… second challenge is to design PAMAM functional dendrimer nanocarriers for the delivery of therapeutics to and through the lungs. Using molecular dynamics simulations, we investigate the microstructures of PAMAM dendrimers as a function of generation, PEGylation density, PEGylation PEG length, …
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Sensitive Detection of Foodborne E. coli O157:H7 by Dendrimer-aptamer Modified Microchannels - with RCA Signal Intensifications
… such diseases in a timely manner. To this end, a dendrimer-aptamer modified microfluidic detection system with rolling circle amplification (RCA) is developed to detect E. coli O157:H7. In the proposed detection system, poly(amidoamine (PAMAM) dendrimers are immobilized onto inner surfaces of …
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Investigation of a Potential Macromolecular MRI Contrast Agent Prepared From PPI (G = 2, Polypropyleneimine, Generation 2) Dendrimer Bifunctional Chelates
Magnetic resonance imaging of this complex resulted in a 52% contrast enhancement in the rat kidney following the agents' administration in vivo.
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Facilitating Non-Covalent Interactions: 'Nanoglue' for DNA-CNT Nanohybrid Complexes
… first and second generation Newkome dendrimers possessing a perylene core were synthesised. Interactions were probed between carbon nanotubes and the perylene core. The DNA binding ability of the dendrimers was tested. As with similar, non polyamine terminated perylene containing …
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Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
… REQUEST.] The novel molecular architecture of dendrimers facilitates use in many applications. Using the solvatochromic probe phenol blue, the first direct examination of the polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimer core cavities was reported by a previous research group …
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