Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Demyelinating Diseases"”.
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
Following the loss of oligodendrocytes in demyelinating diseases such as multiple sclerosis (MS), new oligodendrocytes can be generated from the oligodendrocyte progenitor cell (OPC), a multipotent progenitor cell of the central nervous system. However, the efficiency of this regenerative process …
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Rejuvenation of CNS Progenitors via Partial Reprogramming
… into mature oligodendrocytes following a demyelinating insult with age, and this failure plays a key role in the progression of prominent neurodegenerative and demyelinating diseases, such as Alzheimer’s disease and multiple sclerosis. I have optimised an existing system for isolating OPCs …
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Investigating the protective effects of farnesol formations against neuroinflammation
… are mechanisms associated with CNS demyelinating diseases, we sought to determine whether FOL treatment would result in protection against experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. We demonstrate that there is a correlation between reduced …
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Neural Circuitry Deficits Associated With Dysfunctional Myelin
… the behavioral components of hypomyelinating and demyelinating diseases like multiple sclerosis.</p>
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Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis
… neuropsychological functioning in pediatric demyelinating diseases. Sixty-two pediatric MS and 46 pediatric idiopathic TM participants were administered brief neuropsychological screening evaluations during routine clinical care. Separate profile analyses were conducted on performance-based …
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Functional heterogeneity of oligodendrocyte progenitor cells in the central nervous system
… implicated in the pathophysiology of various diseases including not only demyelinating diseases (eg. Multiple Sclerosis (MS) or Pelizaeus-Merzbacher disease (PMD)), but also psychiatric disorders (eg. schizophrenia or Rett syndrome (RTT)). Regardless of the type of disease, understanding the …
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CNS Remyelination and the Gut Microbiota
… strategies for improving the prognosis of demyelinating diseases such as multiple sclerosis. Data from animal models and human studies have shown that remyelination can occur extensively in the central nervous system (CNS), leading to functional recovery and axonal protection. However, …
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The Role of Fatigue, Depression, and Other Clinical Factors in Determining Cognitive Status in Pediatric Multiple Sclerosis and Transverse Myelitis
… and transverse myelitis (TM) are immune-mediated demyelinating diseases of the central nervous system (CNS). MS is a chronic inflammatory disease that impacts both the brain and spinal cord; whereas, TM is a monophasic condition impacting only the spinal cord. Not surprisingly, cerebral …
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Simulation studies on X-ray imaging of brain parenchyma and tumors
… that are now imaged only with MRI such as demyelinating diseases, dementia, cerebrovascular disease, infectious diseases epilepsy, and brain tumours in early stage. There are many cases reported that brain pathologies (e.g. tumours) have been diagnosed from CT scans performed for completely …
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Molecular interventions to overcome the ageing of CNS stem cells
… is particularly detrimental for patients with demyelinating diseases such as Multiple Sclerosis. The failure of OPCs to differentiate into oligodendrocytes contributes to the progressive worsening of the symptoms with ageing. As such, there is a therapeutic imperative to better understand the …
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Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
… Abnormal SOCE seem to underlie several diseases that notably include allergy, inflammation, acute pancreatitis and cancer. Therefore, any modulator of this pathway is likely to have significant impact in cell biology under both normal and abnormal conditions. In this study, the …
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Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues
… elucidate the mechanisms underlying myelination diseases. First, we improve the existing AA platform to investigate how biophysical cues affect myelin wrapping by rat oligodendrocytes. We build a new high-resolution 3D printer (HR-3DP) that can fabricate AAs with sub-kilopascal elastic moduli and …
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Towards a blood-based biomarker for remyelination: Glial cell death and associated byproducts in demyelinating disease
… for novel applications of liquid biopsies to diseases without characteristic mutational profiles, including many degenerative, ischaemic, infectious, autoimmune, and inflammatory disorders. These events have paved the way for a wide array of neurological conditions to benefit from enhanced …
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LIPID COMPOSITION OF MICROGLIAL CELLS AND EFFECTS OF A REMYELINATION-PROMOTING ANTIBODY ON THE SPHINGOLIPID PATTERNS
… sclerosis (MS) is one of the most prevalent demyelinating diseases among young adults (Lemus et al., 2018). Myelin damage and oligodendrocyte death are caused by the autoimmune attack of T cells that cross the blood-brain barrier resulting in the formation of sclerotic plaques (Pearce, 2005, …
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Stab Wounds to Rat Brains : Demyelination, Remyelination and the Cellular Response, Particularly of Oligodendrocytes
<p>The present body of knowledge concerning the results of central nervous system injury is incomplete and controversial. The role of oligodendrocytes, the cells involved in phagocytosis, the stages of demyelination, and the evidence for remyelination are of interest. Following stab wounds to rat …