Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Demethylating agents"”.
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Investigating the pathogenesis and therapy of Friedreich Ataxia
… the efficacy and tolerability of various DNA demethylating agents, GAA interacting compounds and class III histone deacetylase (HDAC) inhibitors. Although DNA demethylating agents showed increased FXN expression, no correlation between the level of DNA methylation and FXN expression was …
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Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie
… intermediate risk groups. Clinical trials with demethylating agents as 5-aza-2’-desoxycytidine (DAC) und 5-azacytidin (AZA) provided promising findings in therapy of acute leukemias and myelodysplastic syndrome (MDS). We showed, that in hematopoietic tumor cell lines, CpG island hypermethylation …
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Dynamic epigenetic modifications during human fetal germ cell development
… fetal gonads, showed that treatments with DNA demethylating agents are linked to the activation and increase of post-migratory germ cell-specific genes along with meiotic genes in human. To conclude, the results from this study demonstrate that epigenetic changes, such as histone modification …
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Investigating The Impact of Intragenic Dna Methylation On Gene Expression, and The Clinical Implications On Tumor Cells and Associated Stroma
… expression can be abrogated by treatment with demethylating agents. These findings implicate the 3’UTR as a functionally relevant DNA methylation site, particularly regarding T cell activity. Additionally, they reveal a novel mechanism by which <em>HAVCR2</em> is upregulated in T cells, …
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Impact of the DNA methyltransferase inhibitor, 5-azacytidine, on chondrocytic phenotype
… identifying the mechanisms by which DNA demethylating agents alter the chondrocytic phenotype and defining the role of epigenetics in chondrocyte phenotypic stability, control of differentiation and the pathogenesis of OA. The long-term objective of this research program is to develop …
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Diet in the promotion or prevention of colorectal cancer
… to develop a new, simple method to evaluate demethylating agents. We used the CoMeth assay developed in our group in a MMR-deficient cell line, in which one of the intervenients, MLH1, is epigenetically silenced by hypermethylation. Using 5-azacytidine, we were able to revert the …