Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Dementia with Lewy bodies"”.
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Dementia with Lewy bodies —an Investigation of Cause and Consequence
Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are …
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The Role of β-synuclein in the Pathological Mechanisms of Dementia with Lewy Bodies
Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia following Alzheimer’s disease (AD). DLB neuropathology is characterised by Lewy bodies (LBs) and Lewy neurites (LNs) resulting from the modification and aggregation of α-synuclein. The presence of small …
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Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins
… in the pathogenesis of neurodegenerative dementia, including the two most common types, Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). The pathological characteristics of AD include senile plaques, mainly composed of aggregated amyloid-beta peptide (Abeta1-42), but also …
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Validation of brief cognitive tests in mild cognitive impairment, Alzheimer's disease and dementia with Lewy bodies.
… is estimated that 34 million people suffer from dementia, costing society US$422 billion each year. Alzheimer’s disease (AD) is the most common dementia and the global prevalence is predicted to increase to over 100 million people by the year 2050, with the greatest increase in developing …
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Differential expression of proteins involved in sEV biogenesis and secretion in Parkinson’s disease and Dementia with Lewy bodies
… notably Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).<br/><br/>Aims<br/>1. In this study I aim to measure levels of key sEV proteins by focusing on disease-specific brain regions such as the substantia nigra and hippocampus of patients with PD and DLB compared to …
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A study of ultra-high field strength structural and spectroscopic MR imaging in dementia with Lewy bodies and Alzheimer’s disease
… the second commonest form of neurodegenerative dementia, dementia with Lewy Bodies (DLB) is relatively poorly understood, with little research focusing on its pathophysiology or symptomatology in comparison with Alzheimer’s disease (AD) or Parkinson’s disease (PD), to which it is closely …
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Early hippocampal dysfunction in a mouse model of dementia with Lewy bodies: Mechanisms of cellular dysfunction caused by alpha-synuclein accumulation
Dementia with Lewy bodies (DLB) is a devastating neurodegenerative disease, accounting for 5% of all dementia cases, for which there is no cure. Whilst there are currently many different animal models currently available for researchers studying PD, there are comparatively fewer DLB-specific mouse …
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A Multi-Faceted Approach to the Alzheimer’s Disease Proteome: From Human to Mouse Models
… hallmark of Alzheimer’s disease (AD) and related dementias (ADRD). We analyzed the dementia with Lewy bodies disease (DLBD) proteome, a disorder also associated with amyloid pathology, and compared to the AD proteome, identifying conserved alterations in amyloid pathology and shared components in …
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Targeting and Localization of Alpha-Synuclein in Primary Neurons
… conditions such as Parkinson's disease (PD) and dementia with Lewy bodies. Previous studies have shown that alpha-syn normally undergoes delayed localization to presynaptic terminals but the key structural elements involved have not been fully characterized nor the trafficking behavior well …
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The prion-like properties of assembled human alpha-synuclein
… of the inclusions of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, as well as of rarer diseases, collectively called synucleinopathies. For a long time, it was widely believed that neurodegenerative diseases were cell-autonomous; however, a more recent …
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Lewy Body Dementia and the Role of Inflammation
Background: Lewy body dementia (LBD), consisting of Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), is known to make up more than 15% of dementia cases at autopsy, however the clinical prevalence rate is reported to be much lower at around 5-6%. Difficulties with diagnosis …
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Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity
… abnormal aggregation of α-Synuclein (α-Syn) in Lewy bodies (LBs) and Lewy neurites (LNs), are collectively known as synucleinopathies. Even so, tau protein pathology is abundantly found in these diseases. Apart from Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system …
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Alpha Synuclein Oligomers in Human Pathology: Significance of Nitrative Alpha Synuclein Modifications
… such as Parkinson disease (PD) and dementia with Lewy bodies (DLB), which are clinically characterized by motor and cognitive dysfunction. Recent evidence indicates that αSyn oligomer intermediates are the most neurotoxic species. However, the mechanism of action of αSyn oligomers …
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The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders
… genotyping on 1511 post-mortem brain samples within the MRC Brain Bank, we detected 61 monogenic cases of disease, 349 brains carrying disease risk factors, and identified that variants in GRN and PRPH may increase the risk of developing dementia with lewy bodies (DLB) and Alzheimer’s disease …
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Potential Risk Factors Indicating the Likelihood of Aggression and Violence in Individuals with Dementia: a Systematic Review
BACKGROUND: Aggression in individuals with dementia is a common behavioural symptom of the disorder, and has been found to be the most reported source of caregiver distress, and the main reason why an individual will be placed in residential care.<br/>OBJECTIVES: To establish the factors which can …
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Dementia Subtypes, Cognitive Decline and Survival Among Older Adults Attending a Memory Clinic in Cape Town, South Africa: A Retrospective Study
… longitudinal studies from Africa of people with dementia seen in memory clinics. The aim of this study was to determine the proportions of the different dementia subtypes, rates of cognitive decline, and predictors of survival in patients diagnosed with dementia and seen in a memory clinic. …
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MCI IN RBD as a Distinct Clinical Entity: Comparative Evaluation of Diagnostic Frameworks and the cognitive domain as predictive factors of phenotypic conversion
… of dream-enacting behaviors, often associated with vivid and sometimes violent dreams. Increasing evidence supports that RBD represents an early clinical manifestation along the continuum of α-synuclein–related neurodegeneration and a prodromal condition preceding the development of Parkinson’s …
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Studies on the Cytoplasmic Inclusions Detected in Parkinson's disease
… disorders, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Synphilin-1, interaction partner of α-Synuclein is a major component of inclusion bodies, but it is unknown how synphiln-1 contributes to the cellular and biochemical mechanisms of …
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Development and utilization of Luminex biomarker assays for diagnosis and monitoring of neurodegenerative disease
… brain. Neurodegenerative disorders associated with protein misfolding include Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), fronto-temporal lobar degeneration (FTLD), motor neuron disease (MND), Huntington’s disease and the prion diseases. The incidence …
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Investigating the protein targets of the neuroprotective E3 ligase, CHIP
… role in neurodegenerative diseases, including dementia with Lewy bodies, and the severe progeria and proteotoxic phenotype seen in CHIP KO mice support its neuroprotective effects, but the underpinning molecular mechanisms remain largely unknown and understudied. This project aimed to identify …
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