Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Delta-like ligand 4"”.
-
Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
… understood. Here, we demonstrate that the Notch ligand Delta like ligand 4 (DLL4) plays a critical role in this process. DLL4 is essential for the formation of mature blood vessels during development and in several tumor models. Inhibition of DLL4 causes increased vascular sprouting, decreased …
-
EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development
… sprouts. The Notch pathway is activated by the ligand Delta at adherens junctions between tip and stalk cells. Despite the centrality of Delta/Notch signaling to angiogenesis, relatively little is known about the mechanism of this signaling event. It has been proposed that the force generated by …
-
Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… are expressed by the lymphatic endothelium, and Delta-like ligand 4 (Dll4) is the predominantly expressed Notch ligand in the developing lymphatic vessels of the embryonic dermis and pathological lymphatic vessels of the wounded cornea. Dll4 was able to induce Notch activation in human dermal …
-
Development of novel polymeric nanoparticles for pancreatic cancer therapy
… interest is surface modification of the NPs with ligands of specific affinity to improve tumour specific localisation/internalisation and/or produce a therapeutically beneficial effect at the tumour. This concept is explored in the following thesis through conjugation of shark-derived …
-
ELUCIDATION OF THE UNIQUE TRANSLATION OF ANGIOGENIC SIGNALING BY AORTIC VALVE CELLS
… translate angiogenic signals. Next, the pericyte-like capacity of VICs was demonstrated by tracking fluorescently marked VECs and VICs in a long term in vitro angiogenesis co-culture assay. VICs regulated early VEC network organization in a ROCK-dependent manner, wrapping themselves around VEC …