Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Delta-like 4"”.
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Engineered microenvironments for studying liver progenitor differentiation
… we demonstrated that exogenous Jagged-1, Delta-like 1, and Delta-like 4 within the cellular microarray format was sufficient to induce cholangiocytic differentiation. Further, by combining Notch ligand microarrays with shRNA-based knockdown of Notch ligands, we systematically examined the …
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A study of Notch signalling in developmental angiogenesis
… studies have shown that the Notch ligand, Delta-like 4 (Dll4), is prominently expressed in tip cells, therefore suggesting a role of Notch signalling in its regulation. In the mouse, suppression of Notch signalling by pharmacological inhibition of γ-secretase or genetic deletion of one Dll4 …
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DLL4 and JAG1 in the Glioblastoma Response to Temozolomide Chemotherapy
… investigated the effects of the Notch ligands, Delta-like 4 (DLL4) and Jagged-1 (JAG1) on tumour resistance to TMZ and GCSCs. Methods: U87 and U251 glioblastoma cells were transduced with empty vector-, DLL4, and JAG1-encoded retroviruses. Cells were cultured under 2D, 3D, and CSC culture …
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G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
… resulting from G-1, genistein, or BPA exposure likely involved EGFR transactivation, MAPK activation, and reduced levels of vascular endothelial growth factor-a (Vegf-a) and Notch ligand delta like 4 (Dll-4) mRNA. Overall, our findings suggest that GPER activation represents a potentially novel …