Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Delayed type hypersensitivity"”.
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Delayed-type hypersensitivity and cellular immunity to Leishmania donovani
Thesis (M.S.)--Michigan State University. Dept. of Microbiology and Public Health, 1970
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Lack of Delayed-Type Hypersensitivity in Striped Bass (<i>Morone saxatilis</i>)
… tests for mycobacterial infection in fishes. Type IV delayed type hypersensitivity (DTH) responses <em>in vivo</em> and i<em>n vitro</em> are currently used for the non-lethal detection of mycobacterial infections in humans and in animals; however, there is little information available on DTH …
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Studies on Delayed-Type Hypersensitivity Including Attempts to Effect Transfer in Guinea Pigs with Subcellular Materials
<p>The initial observation that delayed-type hypersensitivity could be transferred from an allergic to a normal animal by means of living white cells was made at The Rockefeller Institute many years ago. Since that time it has been recognized that cellular transfer appears to be a unifying …
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Factors affecting the protective effect provided by sand fly saliva immunization on the outcome of Leishmania infection
… the disease outcome. This effect is based on the delayed type hypersensitivity reaction to sand fly saliva which has been shown to peak about 48 hours after antigen encounter, leading to the more effective host immune response towards the Leishmania parasites. In this project, we found this …
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Suppression of T-Helper Cell Function by a Soluble Immunosuppressive Factor From Plasmodium Berghei Infected Rat Erythrocytes
… to mice injected with control preparations. The delayed type hypersensitivity reaction elicited by SRBC was also suppressed in mice treated with the ISF. Purification by affinity chromatography and analysis by SDS-PAGE revealed that the ISF had a molecular weight of approximately 30 KD. Neither …
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Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure to 1,2:5,6 Dibenzanthracene in B6C3F1 Mice
… to the T-dependent antigen, sRBC and the delayed type hypersensitivity response were significantly suppressed at dose levels of 500 µglkg and greater. Mice exposed to DBA in utero and through lactation showed neither immunosuppressive nor sex differences among the immune parameters tested …
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Lymphocyte populations and their relationship to cell-mediated immune responses in aflatoxin-treated guinea pigs
… and weight gain;Passive transfer of delayed type hypersensitivity (DTH) was used to evaluate T lymphocytes or macrophages from aflatoxin-treated guinea pigs. The skin test responses of both nontreated guinea pigs receiving peritoneal exudate cells (PEC) from aflatoxin-treated guinea …
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Etablierung eines infizierbaren Kleintiermodells zur Untersuchung von HIV-Nef
… lymphozytärem Choriomeningitis Virus (LCMV) eine delayed type hypersensitivity (DTH) Reaktion in der Fußsohle von Mäusen induziert werden kann. Tiere, die zuvor neonatal mit Mo-NL infiziert worden waren, zeigten im Vergleich zu Kontrolltieren eine reduzierte CD4-vermittelte T-Zellantwort. Die …
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The Control of Cell Division During the Immune Response
… in the spleen. Parathyroidectomy potentiated the delayed-type hypersensitivity response to oxazolone, perhaps suggesting a selective deleterious effect on a suppressor-cell population. Splenic lymphocytes from parathyroidectomized animals were able to elicit a normal graft-versus-host reaction as …
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Functional characterisation of novel mast cell genes
… on gene expression in various tissue and cell types. Few studies have, however, taken full advantage of these data by selecting and then extensively characterising the functions of particular genes chosen from these microarray datasets. In this study, after analysing differentially-regulated …
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An alternative diagnostic method using microneedles for sampling the immune system in situ
… longitudinal immune monitoring. Whereas delayed-type hypersensitivity tests (e.g., Mantoux tuberculin test) query the presence of antigen-specific cells in the skin, but do not provide information about the phenotype and functional characteristics of responding immune cells. Here we …
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Contagious ecthyma virus infection of sheep: virologic and immunologic investigations
… questions about possible variation of antigenic types of CE virus. It was found that cross-neutralization and delayed-type hypersensitivity tests could not be used to classify the CE viral isolates. However, analysis of the structural polypeptides of CE virions revealed differences among the …
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Development and evaluation of new leprosy skin test antigens as diagnostic tools
… phase II, stage A/B trials using the intradermal delayed type hypersensitivity (DTH) skin test in healthy subjects without known exposure to leprosy, while the phase II, stage C trial compared the DTH skin test to the IFN-γ test and the M. leprae specific phenolic glycolipid I antibody test in …
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Targeting T Cells for the Immune-Modulation of Human Diseases
… To this end, we retrovirally transduced wildtype and miR-23a-deficient CD8+ T cells with the EGFRvIII-CAR, which targets the PepvIII tumor-specific epitope expressed by glioblastomas (GBM). Our in vitro studies demonstrated that while wildtype EGFRvIII-CAR T cells were vulnerable to …
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Effects of exercise on age- and stress- related attenuation of vaccination responses in mice
… OVA into the dorsal side of ear to determine the delayed-type hypersensitivity (DTH) response as a measure of cell-mediated immunity to the vaccination. Ear thickness was measured immediately before and every 24h after intradermal treatment. In the second experiment, two bouts of downhill …
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Understanding buruli ulcer : elucidation of the cellular and molecular mechanisms underlying infection with mycobacterium ulcerans
… have associated cell-mediated immunity (CMI) and delayed-type hypersensitivity (DTH) responses as being protective against M. ulcerans infections, suggesting that the predominantly described histopathology of BU lesions may not reflect the actual host-parasite interaction at the active site of …
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Melioidis: an investigation of cellular immune responses
… inflammation may underlie the susceptible phenotype of this mouse strain toward B. pseudomallei infection. The nitric oxide (NO) secretory activity of C57BL/6 and BALB/c peritoneal macrophages were compared following in vitro stimulation with B. pseudomallei antigens. Comparable levels of NO …