Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Delayed graft function"”.
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Delayed graft function in renal transplantation : aetiology and impact on graft outcome
… significant complications. The most common allograft complication post transplantation is the development of delayed graft function with a reported incidence of between 23 to 34%. This is a costly complication requiring ongoing dialysis and prolonged hospitalization. It also has a significant …
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Mechanisms of Improved Renal Function Following Normothermic Ex-vivo Kidney Perfusion Preservation of Grafts Severely Damaged by Prolonged Warm Ischemia
… (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could improve early function of severely injured donation-after-cardiovascular death (DCD) grafts to reduce the incidence of delayed graft function (DGF). First, we develop a large-animal model of …
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
… (IR) injury makes a major contribution to graft damage during kidney transplantation and increases the risks of primary non-function, delayed graft function and rejection. Oxidative damage to mitochondria is a key early event in IR injury. The aim of this project was to examine the safety …
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Studies of normothermic machine perfusion in human kidney transplantation
… clinical trial to examine the effect of NMP on graft outcomes. NMP for one-hour was deemed to be safe and feasible in renal transplant. Kidneys with a prolonged cold ischaemic time prior to NMP, and extended second period of cold ischaemia after NMP resulted in prolonged delayed graft function …
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MicroRNAs as biomarkers of injury and drug response in renal transplantation
… efficacy of treatment in improving early graft function (HOT2). Increasingly, however, the importance of post-transcriptional regulation is HO-1 is becoming evident, although as yet this is unstudied in humans. The core purpose of this work was to harness microRNAs as biomarkers to predict …
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DIAGNOSI PRECOCE DEL DANNO DA ISCHEMIA RIPERFUSIONE E DELLA DISFUNZIONE RENALE POSTTRAPIANTO: RUOLO DELLA LIPOCALINA ASSOCIATA ALLA GELATINASI NEUTROFILA (NGAL)
L'obiettivo principale della ricerca è stato quello di verificare: - l'utilità di NGAL come marcatore precoce e indice predittivo di DGF nell'immediato post trapianto e se l'andamento di NGAL nella prima settimana dopo trapianto renale presenta specifiche correlazioni con l'andamento del suddetto …
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HOT study: the development, management and results from phase IIB, randomised controlled trial of heme arginate in recipients of deceased donor renal transplants
… transplantation. IRI increases the likelihood of delayed graft function (DGF), which negatively impacts on the long-term survival of a transplanted kidney. One enzyme of interest, heme oxygenase-1 (HO-1), degrades heme and protects against the oxidative stress that occurs secondary to IRI. …
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Characteristics of organ donors and logistics of organ procurement for short- and long-term outcomes in abdominal organ transplantation
… is a medical procedure in which a patient’s dysfunctional organ is replaced with a graft that is usually received from an organ donor. Solid- organ transplantation is the best treatment option especially in end-stage kidney and liver failure. Pancreas transplantation, on the other hand, is the …