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Showing 1 to 2 of 2 for “"Deisgylation"”.
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The roles of papain-like protease-related proteins in viral replication and host immunity
… the PLP2 domain-mediated deubiquitination and deISGylation effects. The infection of nsp2TF/nsp2N knockout mutants significantly upregulated antiviral innate immune responses in vitro. Furthermore, manipulating the expression of nsp2TF/nsp2N could enhance innate and adaptive immunity in pigs, …
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Structural and functional studies of the papain-like protease 2 from mouse hepatitis virus
<p>Our goal is to establish a system to investigate how the deubiquitinating (DUB) and deISGylating activities of coronavirus (CoV) papain-like protease domains (PLPs) are involved in virus immune evasion. To this end, we chose PLP2 from mouse hepatitis virus (MHV) as our target of study because …