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Showing 1 to 20 of 25 for “"Dehydroepiandrosterone"”.
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Dehydroepiandrosterone and dehydroepiandrosterone sulphotransferase activity and expression in human disease
The adrenal steroid dehydroepiandrosterone (DHEA) and its sulphate ester, DHEAS are the most abundant circulating steroid hormones in humans. Uncongugated DHEA predominately exerts its effects via its downstream conversion to active sex steroids in peripheral target tissues. In contrast the …
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Assay procedures for dehydroepiandrosterone
<p>Dehydroepiandrosterone (DHEA) is a 17-ketosteroid which is produced by the adrenal cortex and is excreted in the urine as DHEAsulfate, In diseases of the adrenal cortex, such as adrenal carcinoma or adrenal hyperactivity, the level of DHEA-sulfate in the urine is increased. There are two …
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The in Vitro Effects of the Sulfate Conjugate of Dehydroepiandrosterone on the Incorporation of Radio Phosphate into the Various Fractions of Mouse Kidney Tissue
Phosphorus is prominently associated with mechanisms and structures vital to the maintenance of life in organisms from protozoans to mammals. As phosphate it combines in organic complexes involved in energy transformations within cells. As inorganic phosphate, it associates with calcium in the …
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Intrauterine position in pigs: effects on conceptus development and fetal fluids steroid content
… seven steroids (progesterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, testosterone, estrone and estrone sulfate) were evaluated. Four fetal positions were studied: females between females (f2F), females between males (fOF) , males between females (m2F) and males …
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The relationship of arylsulfatase C and the steroid sulfatases in mammals
… estrone-sulfate sulfatase (E1S-sulfatase) and dehydroepiandrosterone-sulfate sulfatase (DHEAS-sulfatase). They have similar subcellular localization, are membrane bound, have alkaline pH optima, are resistant to inhibition by sulfate and phosphate, and are glycoproteins.
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Význam androgenů adrenálního původu u syndromu polycystických ovarií a hirsutismu
… here. The most abundant adrenal androgen is dehydroepiandrosterone sulfate, whose androgenic potency is not high, but it forms a reservoir in the circulation and can subsequently be metabolized to more potent androgens. Another androgen formed in the adrenal cortex is …
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Effect of extra-gonadal sperm depletion on steroid hormone profiles in semen of bulls
… for testosterone (T), androstenedione (A), dehydroepiandrosterone (DHEA), and progesterone (P) in bovine semen were established for a group of four post-pubertal bulls by depleting the bulls' extra-gonadal sperm reserves (EGR) on three occasions at two week intervals. Each depletion …
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HPA Axis Dysfunction In Treatment Resistant Affective Disorders
… Bipolar Depression (TRBD). In addition, dehydroepiandrosterone (DHEA), the other main adrenal steroid, and which may counteract the effects of cortisol on the brain, has never been measured in TRUD or TRBD. Aims and Methods: To assess the state and relevance of HP A axis changes in …
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The Steroid Sulfatase Inhibitor (p-O-Sulfamoyl) - Tetradecanoyl Tyramine (DU-14) Enhances Memory Retention in Passive Avoidance in Rats with Hippocampal Cholinergic Deficit
Neurosteroids, such as dehydroepiandrosterone sulfate, (DHEAS) are steroidal compounds synthesized within the central nervous system that modulate its function. Among the effects associated with sulfated neurosteroids is the enhancement of memory. Previous studies have demonstrated that altering …
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Rapid social regulation of 3β-HSD activity in the songbird brain
… In contrast, levels of the prohormone dehydroepiandrosterone (DHEA) are elevated year-round in the plasma and brain. The local conversion of brain DHEA to potent androgens may be critical in regulating non-breeding aggression. 3β-hydroxysteroid dehydrogenase/Δ4-Δ5 isomerase (3β-HSD) …
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Synthetic Studies on Small Molecule Modulators of Src Homology 2 (SH2) Domain-Containing Inositol 5’-Phosphatase (SHIP)
… allows for more rapid access to AQX-1125 from dehydroepiandrosterone than the published synthetic pathway, saving time and resources. Key features of the new route include utilizing an allylic oxidation, ozonolysis, and lactonization for a more selective and controlled synthesis. In addition, …
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Understanding the mechanism of androgen biosynthesis
… of an inverse solvent isotope effect during dehydroepiandrosterone formation, as well as functional lyase catalysis by a CYP17A1 mutant possessing an impaired proton-delivery network, strongly support the hypothesis that a ferric peroxoanion is responsible for androgen formation. …
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The synthesis and structural examination of 3alpha, 5-cyclo-5alpha-androstane steroids.
… An improved synthesis of the lead compound, from dehydroepiandrosterone, was achieved. The chemical and spectral implications of the introduction of a-aromaticity into the steroid nucleus is discussed. The synthesis of the ethynyl derivative, was achieved in increasing yields by four different …
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Measuring steroids from dried blood spots using tandem mass spectrometry to diagnose congenital adrenal hyperplasia
… androstenedione, pregnenolone and dehydroepiandrosterone could significantly improve CAH laboratory diagnosis. Although clinical laboratories predominantly use immunoassays to measure some of the above steroids, these assays are hampered by low specificity due to cross reactivity of …
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Tracing Androgen Metabolism With Inhibition Of Aromatase In Breast Cancer: In Vitro Studies And Clinical Correlates
… metabolism of the circulating steroid precursor dehydroepiandrosterone (DHEA) and its sulfate conjugate was assessed in in vitro models of ER+ breast cancer (MCF-7 variant cell lines +/- aromatase). These studies demonstrated estrogen formation from physiological levels of DHEA and DHEA-S in …
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LC-ESI-MS/MS quantification of hair cortisol, cortisone and DHEA in combined oral contraceptive users
… form of cortisol was quantified as well. Dehydroepiandrosterone (DHEA), a hormone that has anti-cortisol activity, was also intended to be added to reflect total cortisol exposure. An in-house LC-ESI-MS/MS method was developed to simultaneously quantify cortisol, cortisone, and DHEA in …
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Salivary VIP concentrations are elevated in humans after acute stress
… with the following salivary indicators cortisol, dehydroepiandrosterone (DHEA) (Morgan et al., 2004) and amylase (Nater et al., 2006) of the stress response. Depending on the stressful situation or stress paradigm, we used an indicator or biomarker profile in conjunction with the use of …
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Regulation of Adrenal Steroidogenesis by Interleukin-6
Cortisol and dehydroepiandrosterone (DHEA) are steroids produced by the zona fasciculata (ZF) and reticularis (ZR), respectively, of the adrenal cortex. Both steroids are upregulated in response to adrenocorticotropic hormone (ACTH). Cortisol is a glucorticoid that is important in the regulation of …
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Effects of intrauterine dynamics on steroidogenesis and conceptus development in the porcine
… position. Only trace amounts of testosterone and dehydroepiandrosterone sulfate were measured in the fetal fluids at all days of gestation. Intrauterine position had no effect on P₄, E₁ or androstenedione concentrations in fetal fluids. Collectively, the results indicated a) a differential release …
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Ein Radioimmunoassay (RIA) für die Messung von Dehydroepiandrosteron (DHEA) im Speichel
Die Messung von Steroidhormonen im Speichel hat viele Vorteile verglichen mit der Messung im Serum. Durch Modifikation eines handelsüblichen Testkits für die Messung von DHEA im Serum stellen wir einen Radioimmunoassay für die Messung im Speichel vor. Der Testkit wurde in seiner Stabilität, …
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