Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Degradable Polymers"”.
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Towards next-generation degradable polymers via double amplification
A refinement of the existing synthetic methods in the literature was developed in order to synthesize tris(aminomethyl)ethanes from pentaerythritol. The result was a scalable, azide free route that produced tris(aminomethyl)ethanol as the trihydochloride salt in high yield. In addition to this …
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Degradable Polymers for the Controlled Delivery of Bioactive Small Molecules
Gasotransmitters are endogenous small molecule gases that are freely permeable to membranes and possess biological signaling functions. The three recognized gasotransmitters are carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S). H2S is featured in this work, as well as persulfides …
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Synthesis and chemical modification of degradable polymers to enhance gene delivery
… ester)s are a class of cationic, degradable polymers that have shown significant promise as gene delivery agents, more effective than the state-of-the-art, commercially available non-viral systems. The main objective of this thesis is to synthesize new poly([beta]-amino ester)s and …
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Studies towards degradable polymers new zinc (II) and palladium (II) complexes as catalysts for lactide polymerization and carbon monoxide
… characterized and used in the production of degradable polymers. Zinc complexes were used for the production of polylactides (PLAs) functionalized with a drug candidate on a polymer tail. These functionalized polymers displayed slow drug release properties under physiological conditions. …
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Rapid, Efficient and Versatile Strategies for Functionally Sophisticated Polymers and Nanoparticles: Degradable Polyphosphoesters and Anisotropic Distribution of Chemical Functionalities
… distributions of chemical functionalities, three degradable polymers synthesized by organocatalyzed ring-opening polymerizations, and two polyphosphoester-based nanoparticle systems for various biomedical applications.</p><p>Inspired by the many hierarchical assembly processes that afford complex …
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Specific ion effects on transient polymers: a new strategy for programmable microcapusles
Transient polymers are emerging materials that transform from macromolecules to small molecules triggered by predefined environmental stimuli. Distinct from traditional degradable polymers, transient materials undergo domino like chain unzipping reactions, leading to controlled and complete …
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Mechanochemical Reaction Development for Addition, Elimination, and Isomerization
… of covalent chemical reactions in isolated polymers and in bulk polymeric materials. Mechanochemical reactions have been widely used in mechanocatalysis, release of small molecules and protons, biasing and probing reaction pathways, stress reporting, stress strengthening and degradable …
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A Multicomponent Bioactive Tissue-Engineered Blood Vessel: Fabrication, Mechanical Evaluation and Biological Evaluation with Physiological-Relevant Conditions
… with graft materials, we demonstrated a degradable polyester-fibroin composite tubular scaffolds which shows well-integrated nanofibrous structure, endothelial-conducive surface and anisotropic mechanical property, suitable as engineered vascular constructs. Tissue regeneration needs not …
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Sustainable Polymers Through Creative Design
… on new strategies for developing renewable and degradable polymers with minimal energy input as well as new methods to blend legacy polyolefins with renewable polymers. The first half of the dissertation focuses on synthesizing polymers using light while the second section focuses on combining …
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Development of acid-amplifying polymers
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Stimuli-Responsive Polymer Systems that Respond to Redox Potential and pH for Controlled Drug Release
… and report on the synthesis of fully degradable poly(disulfide) cross-linked nanogel drug carriers formed by oxidative radical polymerization of 2,2'-(ethylenedioxy)diethanethiol (EDDET) as a monomer with different cross-linkers, including pentaerythritol tetramercaptoacetate (PETMA), …
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Biodegradation, surface rugosities and biofilm coverage of biopolymers
… resulted in the emergence of a wide range of biopolymers. The biodegradability of these alternative biopolymers requires investigation prior to their application in environmental and medical systems. This Thesis describes biodegradation of poly(3-hydroxybutyrate) (PHB), …
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Azomethine-Containing Moieties for Simple and Degradable Conjugated Polymers
<p>Conjugated polymers have been studied for various applications such as electrochromics, organic photovoltaics, organic light-emitting diodes, thin film transistors, biosensors, and energy storage materials. They have received significant attention from many researchers because they are …
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Design and Synthesis of Stimuli-Responsive Polymers with Programmable Cleavability
Polymers comprise a large portion of modern-day materials, from everyday plastics that we can hold and use, to nanomaterials imperceptible to the naked eye. Applying synthetic chemistry to impart structural changes to established polymers offers a promising path to introduce novel functionalities …
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Hybrid Electrospun Transcatheter Aortic Heart Valves for Tissue Engineering Applications
… of producing electrospun scaffolds with both degradable and reinforcing, non-degradable, fibres to improve mechanical properties and allow for improved control over degradation rates to avoid catastrophic valve failure due to premature valve degradation and inadequate tissue ingrowth. …
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Stimuli-responsive microcapsules for self-protecting and self-healing material systems
… size reliably based on process parameters. Photo-degradable microcapsules are reported with cPPA shell wall containing an oil (single emulsion-templated) or aqueous (double emulsion-templated) core. Photo-responsive properties are achieved by incorporating a photoacid generator (PAG) additive to …
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Synthesis and kinetic processes in designed polymers
Traditional polymers have been long used for commercial products from polyester shirts to polyvinyl chloride (PVC) pipes or even polytetrafluoroethane (Teflon) non-stick coatings. As the needs of our society grow and change, innovative solutions must be created to overcome the challenges that …