Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Degenerative Disease"”.
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Somatic Mutations in Ageing and Degenerative Disease
… the development of age- related phenotypes and degenerative disease. To accurately characterise the mutational processes in normal tissues, we developed nanorate sequencing (NanoSeq), a duplex sequencing protocol with error rates of less than five errors per billion base pairs, allowing for the …
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Effects Of Altering The Peroxisomal Redox State In Models Of Degenerative Disease
… and that produce an array of anti-aging and disease processes. However, as cells age over time, ROS amass within the peroxisome and elsewhere in the cell. This leads to an imbalance in oxidative homeostasis and results in compromised signaling networks. The goal of this dissertation was to …
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An initial evaluation of the relationship between human pelvic size and shape and the distribution, type and severity of vertebral degenerative disease in archaeological material
… shape; pelvic dimensions;vertebral degenerative disease. In order to adopt an efficient bipedal postureand method of locomotion, tile human skeleton has evolved a curved vertebral column and a stable, compact male pelvic girdle. Adaptive vertebral curves and the force of gravity …
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Invisible scars : how domestic violence victims have been left out of the discussion on traumatic brain injuries
… extends to chronic traumatic encephalopathy, a degenerative disease caused by repetitive hits to the head. Although domestic violence researchers suggest that the population will develop CTE, which is only diagnosed post-mortem, a lack of donated brains means the disease has yet to be found …
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Η ΣΥΧΝΟΤΗΤΑ ΤΗΣ ΨΕΥΔΟΑΠΟΦΟΛΙΔΩΣΗΣ ΣΤΗΝ ΗΠΕΙΡΟ
… FOR THIS AREA WAS 20%. PSEUDOEXFOLIATION IS A DEGENERATIVE DISEASE, MORE FREQUENTLY FOUND IN THE OLDER PEOPLE. 40% OF THE PATIENTS WITH PSEUDOEXFOLIATION HAD OCULAR HYPERTENTION. PATIENTS WITH PSEUDOEXFOLIATION WHO HAD EXFOLIATION MATERIAL AND HIGH DEGREE OF PIGMENTATION AT THE ANGLE,HAD MORE …
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To disclose or not to disclose: a phenomenological and autoethnographic account of teaching while living with a hidden illness
… 130,000 people in the UK (PHE, 2020). It is a degenerative disease of the central nervous system, currently without a cure, which can affect a wide range of physical and cognitive functions. Whilst there are many studies that explore the impact of the disease for those who have been diagnosed …
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Process of Health Care Decision Making Among Khmer Immigrants
… and cultural comfort regardless of distance. Disease prevention was linked to adequate food quantity. Chronic degenerative disease, stress, and reproductive complications were reported frequently. The adolescents and women appeared to be at high risk for cultural stress.</p>
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Behavioral impulsivity and hallucinations : insights from Parkinson's disease
Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, including hallucinations and impulse control behaviors, stem from the …
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Surgery for Degenerative Mitral Valve Disease:Earlier Intervention, New Procedures, and Better Outcomes
… evolution of surgical techniques for degenerative mitral valve (MV) disease, and effects of these changes on surgical morbidity and mortality and hospital stay.Methods: From 1985 to 2010, 7,982 patients underwent surgery for degenerative mitral regurgitation; 5,045 had isolated MV …
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From Protein Structure to Clinical Strategy: An In silico Investigation of Mitochondrial DNA Mutations in Type 2 Diabetes and Degenerative Disc Disease for Targeted Nutritional Interventions
Non-communicable diseases (NCDs), including Type 2 Diabetes Mellitus (T2DM) and Degenerative Disc Disease (DDD), represent major contributors to global morbidity and mortality, particularly within low- and middle-income countries where aging populations and chronic metabolic stress intersect. …
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Rod Photoreceptor Regeneration in a Zebrafish Model with Retinitis Pigmentosa
<p>A cellular hallmark of inherited retinal degenerative diseases is progressive loss of photoreceptors until one is completely blind. Unlike mammalian models, Zebrafish have the ability to naturally regenerate their neurons after injury or disease is detected. We have generated a zebrafish model …
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MRI Assessments of Adjacent Disc Degeneration of Lumbar Fusion Group versus Discectomy Group
… patients who underwent spinal surgery for lumbar degenerative disease by thecorresponding author and taken minimal 2 years follow-up MRI were included in this study. Of these, we regarded 34 patients of lumbar fusion as study group and 22 discectomy patients as control group. The MRI Thompson …
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Perceptions of Dementia Across Students in Health Professions Programs at Texas State University
Background: Dementia is a progressive degenerative disease that can result in decline of cognitive functioning. Individuals with dementia often seek therapy or treatment from a variety of health professionals. Due to the rising incidence of dementia in the world, it is important that future …
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Parkinson's Disease Automated Hand Tremor Analysis from Spiral Images
Parkinson’s Disease is a neurological degenerative disease affecting more than six million people worldwide. It is a progressive disease, impacting a person’s movements and thought processes. In recent years, computer vision and machine learning researchers have been developing techniques to aid in …
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Hedgehog Signaling Modulates Cholesterol Homeostasis in Chondrocytes and in Osteoarthritis
Osteoarthritis (OA) is a common degenerative disease of the joint that is characterized by degradation and calcification of articular cartilage, and subchondral bone changes. Hedgehog (Hh) signaling is known to be activated in human and murine OA. Since Hh signaling regulates Gli-mediated gene …
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Effects of physical activity and exercise on physical and mental health outcomes in female older adults with arthritis
Background: Arthritis is a chronic, degenerative disease, which affects two million older Canadians, of which the majority are older females (65+ years). With no cure, methods to improve arthritic symptoms are essential to maintain physical and mental health. Physical activity (PA) and exercise may …
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MR assessment of the adjacent segment degeneration after discography
… 17) who had undergone a spine surgery for lumbar degenerative disease with preoperative provocative discography were included in this study. Each patients had both preoperative and a minimum of 5-year follow-up MRI. Subject discs were grouped as adjacent discs of fusion (62 discs), and non-fusion …
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The independent and combined effects of rapamycin and metformin on naturally occurring osteoarthritis
Osteoarthritis (OA) is among the top 10 diseases limiting human healthspan, and no disease modifying therapies currently exist. OA is a degenerative disease of the whole joint, characterized by articular cartilage loss, subchondral bone sclerosis, meniscal calcification, synovitis, and skeletal …
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