Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Definitive endoderm differentiation"”.
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The effect of replication impediments on differentiation
… this thesis I set out to answer the question ‘is differentiation robust to replication impediments?’. Prior work in the group has focussed on the epigenetic impact of replication impediments in the terminally differentiated DT40 chicken cell line. I wanted to find out whether these impediments …
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DNA topology and Pol II CTD phosphorylation as stepwise regulators of chromatin architecture in differentiating human stem cells
During differentiation, pluripotent cells must commit to one of many possible lineages. This commitment is mediated by RNA polymerase II (Pol II), which is recruited by transcription factors, guided by enhancers, excluded from heterochromatin, and repositioned through DNA looping. While each of …