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Showing 1 to 20 of 23 for “"Defensins"”.
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Defensins In Ocular Immunity
… at both 1 and 5 days p.i. when silencing both defensins. PMN</p> <p>infiltration was increased at 1 day p.i. by silencing both defensins or mBD3, but not</p> <p>mBD2 alone. iNOS expression was elevated by silencing mBD2, but reduced after</p> <p>silencing mBD3 or both defensins. Additionally, …
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Role of human β-defensins in human burn wounds
… cause of morbidity and mortality. Human Β Defensins (HBD) are a group of recently discovered antimicrobial peptides. The main subtypes include HBD1, 2 and 3 and are individually known to have other functions apart from being anti-microbial. Some of these are inherently expressed while …
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Detection of human salivary α-Defensins by LC-ESI-MS and evaluation of levels in athletes after physical stress
… the level of individual human neutrophil alpha defensins (HNP1-4) after physical stress. A method for the analysis of individual (HNP1-4) in a saliva matrix by LC-ESI-MS has been established. An Agilent 1200 series HPLC, coupled with a Synapt G1 (Q-TOF-ESI-MS), was used for the separation and …
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Activity of Epithelial Defensin HBD-3 Against a Periodontal Pathogen
<p>Defensins are cationic (positive-charged) peptides with broad-spectrum antibiotic activity. In humans, there are two types of defensins, alpha (α) and beta (β). Human neutrophils contain four α-defensins known as Human Neutrophil Peptide (HNP) 1-4. Epithelial cells produce four β-defensins known …
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Sequencing and functional characterization of a Latrodectus geometricus defensin, Lg-defensin
<p>Defensins are small, cysteine-rich, immune related proteins described to be the most widespread family of invertebrate antimicrobial peptides. Presently, there is limited information regarding spider defensins. In this study, a new defensin peptide was described in <em>Latrodectus geometricus, …
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Antimicrobial Activity of Human Leukocyte Defensin HNP-4 Against Gram-negative Bacteria
… cells) contain four peptides known as alpha (α)-defensins or HNP 1-4. The peptides have broad-spectrum antibiotic activity. HNP 1-3 are major neutrophil components. They differ by only one amino acid residue. HNP-4 is found in small amounts, and has a different sequence. HNP-4 purified from …
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Self-assembly of human defensin 6 and its role in innate immunity and siderophore-based strategies to target Gram-Negative bacteria
… cells. This activity of HD6 is unusual among defensins. Herein, we employed biophysical and biological techniques to decipher the molecular details of the unusual behavior of HD6. We demonstrate that the self-assembly of HD6 is driven by hydrophobicity and this work highlights how variable …
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Temporal and Tissue Specific Changes in Expression of Nutrient Transporters and Host Defense Peptides in Young Broilers during Salmonella and Campylobacter infections
… of nutrient transporters and avian beta-defensins (AvBD) vary by day, tissue and challenge dose. ZnT1 may play an important role during a Salmonella challenge as mRNA abundance of ZnT1 significantly increased (P<0.05) by day 7 in the 108 group compared to the control. Early changes in …
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Ontogeny and biological function of epithelial cells in the chicken yolk sac and small intestine
… epithelia and the yolk sac secrete beta defensins for promoting intestinal health. Since there are heterogeneous cell types along the mammalian intestinal villus, which are derived from the intestinal stem cells in the crypts, we investigated if cells of the chicken yolk sac and small …
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A study on the application of synthetic antimicrobial peptides derived from plants for the reduction of yeast spoilage in food
… barley peptide D-lp1) from the family of plant defensins, as well as their characteristics (mechanism of action, safety, stability) and applicability in various food products to reduce the growth of spoilage yeast. Both radish defensins were successful in reducing the growth of the yeast, with …
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Developmental gene expression of host defense peptides in immune organs and the small intestine of turkey poults (Meleagris gallopavo)
… are three classes of avian HDPs: avian beta defensins (AvBDs), cathelicidins (Cath) and liver-expressed antimicrobial peptide 2 (LEAP-2). The objective was to compare expression of HDPs in male turkey poults at day of hatch (D0), D7, D14, D21 and D28 from the thymus, spleen, bursa, duodenum, …
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Evolutionary forces shaping innate immune gene variation in a bottlenecked population of the Seychelles warbler
… selection within this system by using avian beta-defensins and toll-like receptor genes to examine functional variation. First, I characterise variation within both gene groups in this population and show that this species’ demographic history has had an overriding effect on selection and random …
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On the discovery and biological characterization of porcine β-Defensin 5 (pBD-5)
… Host defense peptides (HDPs), such as porcine β-defensins (pBDs), have gained attention for their immunomodulatory, microbiome-modulating, and antimicrobial properties. This thesis describes the discovery, synthesis, and biological characterization of a novel porcine β-defensin, pBD-5, and its …
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Molecular and morphological studies on non-healing venous leg ulcers.
… significantly increased levels of chemotactic ?-defensins, as well as heparin binding protein (HBP), a factor known to induce capillary leakage. Secreted products of Pseudomonas aeruginosa, a bacterium often present in chronic ulcers, were found to induce release of HBP from human neutrophils. …
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Cellular Events During Coccidial Infection in Chickens
… in the target tissues, while the avian beta-defensins (AvBDs) showed many variations in expression patterns. Downregulation of LEAP2 may be a mechanism for Eimeria to combat the host defense system, and to promote its survival inside the host cell. The in situ hybridization results showed …
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Vip And Host Immunity
… growth factors, angiogenic molecules and beta defensins in the infected cornea; that it reduced pro-inflammatory, but increased anti-inflammatory TLRs after corneal infection; and that it is not required for growth factor production in the normal cornea but required in the infected cornea to …
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Geographic and Ontogenetic Variation of Venom in the Rattlesnakes Crotalus oreganus oreganus and Crotalus o. helleri
… existed, with small basic peptides (myotoxic β-defensins) expressed in large amounts by all populations, metalloproteinases abundant in two populations but only moderate and trace amounts in the other two populations, and a potent presynaptic neurotoxic phospholipase A2 present in just one …
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건선 피부에서 Toll-like receptors와 antimicrobial peptides의 발현과 혈청 내 비타민 D과의 관계
… antimicrobial peptides (AMPs) such as human beta defensins (HBDs) and cathelicidins (LL-37) can modulate the immune system through a variety of ways in psoriasis. Purpose: The objective of the present study was to determine, whether epidermal keratinocytes of psoriatic skin show overexpression or …
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An integrated top-down and bottom-up proteomic platform to reveal potential salivary biomarkers of the rare disorders SAPHO syndrome, Wilson’s disease and Hereditary angioedema
… The observed increase of the level of α-defensins 2 and 4 may give a contribution to the development of the disease by the improvement of the free copper. The proteome of patients affected by SAPHO syndrome revealed a significant decrease of cystatins, histatins, and aPRPs, which are …
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