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Showing 1 to 20 of 29 for “"Decorin"”.
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Extracellular Proteoglycan Decorin in Bovine Mammary Physiology
… transcription, protein synthesis, and secretion. Decorin is an ECM proteoglycan known to impact mammary cell proliferation in humans and rodents. Prior to this work, very little was known about decorin in bovine mammary biology. A series of bovine mammary cell culture experiments was conducted. …
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Relationships Between Decorin and Biglycan, Structure and Tendon Mechanics Using Mutant Mouse Models
… structure and composition with a focus on decorin and biglycan, two Class I SLRPs. Utilizing homozygous null and heterozygous mutant genotype mouse models, the amount of SLRPs were varied to allow for the study of the "dose" response on tendon mechanics. A statistical model was used to …
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Synthetic peptides derived from decorin as building blocks for biomaterials based on supramolecular interactions
… block, based on synthetic peptides derived from decorin, is presented. These peptides represent a promising basis for the design of polymer-based biomaterials that mimic the ECM on a molecular level and exploit specific biological recognition for technical applications. Multiple sequence …
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Screening auf Interaktionspartner für den hämatologischen Rezeptor PRV-1 : PRV-1 interagiert mit Decorin, C1qB und Defensin alpha 3
… Assay etabliert. Darüber konnte für die Proteine Decorin, C1qB und Defensin in vitro eine physikalische Interaktion mit PRV-1 nachgewiesen werden. Während C1qB und Defensin eine schwächere Interaktion zeigten, ließ sich für Decorin eine starke Bindung an PRV-1 nachweisen. Da die cDNA Bank oft nur …
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Charakterisierung von humanen mesenchymalen Stammzellen und Zellen der osteoblastären Differenzierungskaskade
… ergaben Bone Sialoprotein, Osteocalcin, Decorin sowie Kollagen-IV und Kollagen-X unterschiedliche Färbemuster. Kollagen-IV und –X waren besonders in hMSC positiv, weswegen sie sich für eine Erkennung unreifer osteoblastärer Zellen anbieten. Bone Sialoprotein, Osteocalcin und Decorin …
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Germline HOXB13 G84E Mutation Inhibits MEIS1-HOXB13 Driven Tumor Suppression in Prostate Cancer
… a significant reduction in the proteoglycans, Decorin and Lumican. Exogenous addition of Decorin and Lumican reduced growth and migration of PrCa cell lines. These data support the HOXB13-MEIS1 axis in PrCa while providing a foundation for emerging proteoglycan therapies in the CRPC space when …
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Knochenzellwachstum im dreidimensionalen Zellkultursystem
… die Nachweise für Alkalische Phosphatase und Decorin negativ. Im Vergleich zu den 3-D-Kulturen war in der stimulierten 2-D-Kultur die Markierung von Osteocalcin deutlich schwächer ausgeprägt. Ohne osteogene Stimulation konnten in den 2-D-Kulturen positive Nachweise für Kollagen I, Kollagen IV, …
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Effect of Electrospun Mesh Diameter, Mesh Alignment, and Mechanical Stretch on Bone Marrow Stromal Cells for Ligament Tissue Engineering
… of the ligament-like markers collagen type I and decorin were enhanced on the smallest fiber diameters compared to larger diameters. In the second study BMSCs — seeded onto aligned electrospun PEUUR scaffolds — were cyclically stretched to determine the effect of dynamic mechanical stimulation on …
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The effect of potential anticancer gene products on breast cancer cell lines
… three different potential anticancer factors, decorin, interferon beta (IFNb), and tumor necrosis factor (TNF) related apoptotic inducing ligand (TRAIL). The overall hypothesis was that combinatorial treatment of two of anti-cancer factors would be more efficacious and exhibit less toxicity …
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Impact loading and functional tissue engineering of articular cartilage
… collagen type II, but not collagen type I. Decorin decreased following C-ABC treatment, but recovered during subsequent culture. The known ability of decorin to control collagen fibrillogenesis suggests a putative mechanism for C-ABC's effects. Diseased articular cartilage heals poorly. For …
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Comparison of bone marrow mesenchymal stem cells and tendon progenitor cells cultured on collagen surfaces
… cartilage oligomeric matrix protein (COMP), and decorin on day 7. Glycosaminoglycan (GAG) synthesis was analyzed on day 7. Differences of cell number between collagen groups and cell type, and in gene expression and GAG synthesis between collagen groups and cell types, were evaluated by use of …
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CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
… (sox9, sox6, l-sox5, type II collagen, aggrecan, decorin and link protein). Real-Time PCR, Western blot and Immunofluorescence reveal that CCN2 is required for the early stages of chondrogenesis, including expression of sox6 and aggrecan, but not type II collagen. Furthermore, focal adhesion …
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Targeting the myofibroblast : new strategies in managing equine corneal fibrosis
… is safe and effective and when delivering decorin, a natural antagonist of transforming growth factor beta, fibrosis is significantly inhibited in vitro. Additionally the histone deacytelase inhibitor suberoylanilide hydroxamic acid is an effective inhibitor of equine corneal fibrosis in …
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Βιοχημικές και ανοσοβιολογικές μεταβολές των πρωτεογλυκανών σε κακοήθη νεοπλάσματα του γαστρεντερικού συστήματος
… στο παγκρεατικό καρκίνωμα, η versican και η decorin. Και οι δύο πρωτεογλυκάνες εντοπίστηκαν στο στρώμα και απουσίαζαν πλήρως από τα καρκινικά κύτταρα, γεγονός που υποστηρίζει ότι παράγονται από τις ινοβλάστες του στρώματος. Ήταν σημαντική η αύξηση των ποσοτήτων των δύο πρωτεογλυκανών στο …
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In Vitro Equine Flexor Tendonitis: New Model Development and Therapeutic Investigation
… cartilage oligomeric matrix protein (COMP) and decorin. Data will be analyzed by analysis of variance and post-hoc comparisons. Significance will be set at p<0.05. We hypothesize that the addition of exogenous PGE2 to culture media for monolayers of equine tendon fibroblasts will insight …
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An investigation into the anatomical and proteomic properties of the anterolateral ligament (all)
… including type I collagen, type III collagen, decorin, biglycan, fibronectin, and tenascin-C-proteins characteristic of load-bearing ligaments. The FCL showed higher collagen abundance, and the ALL demonstrated high levels of decorin (20-22). In conclusion, this study provides new anatomical, …
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An Evaluation of Transforming Growth Factor-β Signalling in Adult Glioblastoma
… Excel and GraphPad Prism. The small proteoglycan decorin (DCN) was then explored as a potential therapeutic using in vitro cell biology assays, namely proliferation assays and Western blotting. <br/><br/><b>Results</b>: The bioinformatics data highlighted TGFβ2, SMAD7 and SARA as potential targets …
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Functions of small leucine-rich repeat proteoglycans in connective tissues
… for the physiological requirements. For example, decorin and lumican interact with collagen using their central leucine-rich repeat domains, while fibromodulin makes use of its C-terminal domain. In addition, some SLRPs can inhibit each other's binding to collagen. These differences, together with …
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Adipose-Derived Adult Stem Cells as Trophic Mediators of Tendon Regeneration
… protein expression (collagen types I and III, decorin, and cartilage oligomeric matrix protein) by TFBLs. Media conditioned by ADCs induced ADC migration in a dose dependent manner. These findings support the role of both SVF and ADCs as trophic mediators in tendon regeneration. The differences …
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Porcine urinary bladder matrix in an in vitro equine model of tenogenesis
… aspect ratio, DNA, or glycosaminoglycan content. Decorin, matrix metalloproteinase 13, and scleraxis expression increased significantly over time, but not in response to UBM treatment. Mohawk expression was constant over time. Cartilage oligomeric matrix protein expression decreased over time in …
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