Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Decitabine"”.
-
Single Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms
… and relapse/refractory AML patients treated with Decitabine and Venetoclax (Dec+Ven). We found that genetic factors, such as complex cytogenetics, KRAS and TP53 mutations, were significantly associated with initial treatment resistance. However, phenotypic factors, including bone marrow …
-
Exposures and the Impacts on the Epigenome that Persist from Youth to Adulthood and Intergenerationally
… chemotherapeutic drug 5-aza-2'-deoxycytidine (Decitabine), both of which disrupt different elements of the DNA methylation pathway resulting in persistent epigenetic changes. I first share my findings on the impacts of maternal arsenic exposure, which disrupts the 1-carbon metabolism pathway. I …
-
The role of Ten Eleven Translocation enzymes in the hair follicle mesenchyme
… methyltransferases (DNMT’s) can be degraded by decitabine which reverses gene silencing. Conditional knockout of Tet2 in mouse DP cells results in a delay in anagen initiation, suggesting Tet2 is involved in the telogen-anagen transition. Additionally, by using dermal fibroblasts and RA-DPAC …
-
Studies On The Determinants Of HIV Mutagenesis And Strategies For Its Enhancement
… and HIV-2 have different mutation rates; 2) decitabine, a HIV-1 mutagen, creates G-to-C transversion mutations in the absence of mutational hotspots; 3) 5-azacytidine causes HIV-1 mutagenesis after reduction to 5-aza-2’-deoxycytidine (i.e. decitabine); 4) the anti-HIV-1 activity of …
-
Investigating the impact of pharmacological exposures on the developing epigenome
… regulation in vitro. 5-azacytidine (AZA) and decitabine (DAC) are both cytidine nucleoside analogues used in the treatment of acute myeloid leukaemia. Following incorporation into DNA, both drugs have been demonstrated to induce depletion of DNA methyltransferases (DNMTs), removal of DNA …
-
Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… dependent for three ALDH isoforms (1A1, 2, 3A1). Decitabine treatment led to enhanced protein expression for ALDH1A1 (A549), ALDH2 (MCF7) and ALDH3A1 (A549). In contrast, the protein level was reduced for ALDH1A1 in HT29 cells after decitabine treatment. ALDH1A1, ALDH2 and ALDH3A1 were highly …
-
Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… dependent for three ALDH isoforms (1A1, 2, 3A1). Decitabine treatment led to enhanced protein expression for ALDH1A1 (A549), ALDH2 (MCF7) and ALDH3A1 (A549). In contrast, the protein level was reduced for ALDH1A1 in HT29 cells after decitabine treatment. ALDH1A1, ALDH2 and ALDH3A1 were highly …
-
Targeting integrin alpha 5 and focal adhesion kinase to overcome azacitidine resistance in higher risk myelodysplastic syndromes
… acute myeloid leukaemia. Azacitidine (AZA) and decitabine are the only available therapies for higher risk myelodysplastic syndromes shown to improve the overall survival in these patients. However, primary and secondary resistance results in treatment failure in virtually all patients. Integrin …
-
Spectroscopic analysis and synthesis of nucleoside analogs for lethal mutagenesis
… many of them, including 5-aza-2'-deoxycytidine (decitabine), did not show multiple tautomers and thus had other molecular mechanisms behind their mutagenicity. This suggested that breaking the aromaticity of the nucleobase in KP1212 had a significant effect on the distribution of tautomers. To …
-
The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
… The combination of the DNMT inhibitor decitabine with the AurkA inhibitor MLN8237 enhances differentiation and reduces proliferation compared to either agent alone. Importantly, the combination of clinically achievable doses of these targeted agents dramatically reduces tumor growth in …
-
Development of a Lentivirus-mediated Gene Therapy Targeting HIV-1 RNA to Eliminate Infected Cells
… analogue DNA methyltransferase inhibitor decitabine (DAC) is an adjuvant of the HIV-1-targeted cell suicide system, with DAC-TP and GCV-TP known to synergise. A ≥65% reduction in J-Lat 10.6 viability was achieved when cells were stimulated with BTZ, DAC, or a TNFα/DAC ‘shocktail’ prior to …
-
Analysis of prognostic and drug resistance markers in lung cancer
… the LS310 cell line with the demethylating agent decitabine increased its cisplatin sensitivity as well as increasing the level of MLH1 expression of the cell line. No such changes were demonstrated in the LS274 cell line after treatment with decitabine. In summary, this research project was …