Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Decarboxylative"”.
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Development of decarboxylative strategies towards the synthesis of fluorinated pharmacons
Fluoro(oxo) functional groups, such as trifluoromethyl ketones, difluoromethyl ketones, and trifluoroethanols, have emerged as desirable motifs in medicinal chemistry for the fine tuning of pharmacokinetic properties. Over the past few decades, fluoro(oxo) diversity has been accessed through …
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Decarboxylative Transformations Facilitated via Intermolecular Halogen Transposition using gem-Bromonitroalkanes
Carboxylic acids offer a sustainable alternative to fossil-fuel derived feedstocks. These shelf-stable and highly abundant substrates can be sourced from renewable biological sources in the form of amino acids, fatty acids, and sugar acids. In addition to being readily available, their facile …
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New Methods for Palladium-catalyzed Decarboxylative Benzylation, Arylation and Dearomatization Reactions
… synthesis. In this regard, palladium-catalyzed decarboxylative cross-coupling has significant potential as a waste-free reaction manifold with increased functional group tolerance due to the avoidance of preformed organometallics and basic reagents. Since the initial reports by Saegusa and Tsuji …
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The selective palladium-catalysed decarboxylative coupling of nucleophiles in the presence of propargylic electrophiles
… a palladium-catalysed chemo- and regioselective decarboxylative coupling of 1,3-dicarbonyl compounds and nitrogen nucleophiles in the presence of propargylic electrophiles. The first part of this thesis focuses on the palladium-catalysed cross-coupling reaction involving two 1,3-dicarbonyl …
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Decarboxylative Strategies in Cobalt and Metallaphotoredox Catalysis: Approaches to Aroylation, Allylation, and Strain-Driven Reactivity
Herein, the design of distinct decarboxylative strategies to access synthetically valuable molecules is described. The primary goal has been to achieve environmentally friendly cross-coupling reactions that align with the principles of green chemistry. This was successfully achieved through the use …
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Investigation of artificial malonyl group carriers and multifunctional cyclic scaffolds towards the mimicry of PKS
… the more suitable artificial malonyl carriers in decarboxylative aldol-type condensations. In the second part of the thesis, the first example of a base and metal -free decarboxylative aldol condensation is described. Three different catalytic systems have been successfully employed to carry out …
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Radical decarboxylation strategies for the synthesis of nitrogen-containing heterocycles
… a sequential oxidative radical cyclization-decarboxylative-dimerization process from β-oxoacids, forming three bonds in a one-pot manner. This approach was successful with a diverse range of 3,3′-bisoxindoles substrates obtained in up to 96% yield. The second part of chapter two details a …
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Applications of Cobaloxime/Photoredox Co-operative Catalysis Toward Olefin Functionalization
… has been achieved through the development of decarboxylative transformations and olefin activation processes that allow access to reactive intermediates via light-driven catalysis. When carried out in the presence of cobaloxime catalysts, a cobalt complex designed to mimic vitamin B12, olefin …
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Exploration of Synthetic Pathways to Quaternary Carbon Stereocenters and Fused Ring Systems via Birch Reductions
… We report efforts toward cyanthiwigin F via a decarboxylative allylation as well as an enantioselective Birch – Heck sequence to make 6-5-6 and 6-6-6 carbocyclic and heterocyclic systems. In all of these examples the Birch reduction alkylation has been the key step and we have demonstrated …
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Part I. Approaches Toward the Total Synthesis of Tyloindicine F; Part II. Palladium-Catalyzed C−H Functionalization of β-enaminones
… for β-enaminone C-H functionalization and the decarboxylative coupling of β-enaminones were also investigated.
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Functional Evolution of Solute-Binding Proteins
… entropic penalty to binding. CDT catalyses the decarboxylative aromatisation of prephenate and arogenate; these reactions are involved in phenylalanine biosynthesis. Because CDT is closely related to non-catalytic SBPs, this enzyme provides a useful model system for understanding the emergence …
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Functional Evolution of Solute-Binding Proteins
… entropic penalty to binding. CDT catalyses the decarboxylative aromatisation of prephenate and arogenate; these reactions are involved in phenylalanine biosynthesis. Because CDT is closely related to non-catalytic SBPs, this enzyme provides a useful model system for understanding the emergence …
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Photodecarboxylative additions to phthalimides and their application in the synthesis of AKS-186 and its analogues
… of novel pharmaceutical lead compounds. The photodecarboxylative addition of various carboxylates to phthalimides has been developed in our group as a powerful access to hydroxyl- and methylene-isoindolinones. Likewise, the intramolecular version yields the corresponding cyclisation products. In …
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Designed Bond Cleavage Reactions for Next-Generation Therapeutics
… until activated by a rapid C–C bond-cleaving decarboxylative elimination reaction. Further, we propose an in situ generation of reactive species for the protein of interest in disease cells. The prodrug can be selectively activated by caging the reactive Michael acceptor with a carboxylate …
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Anion Relay Cyclopropanation and Aryl Vinyl Cyclopropane Cope Rearrangements
… of allylic alcohols and its application to decarboxylative and deacylative allylation reactions (DcA and DaA). This synopsis is followed by an overview of a novel anion relay cyclopropanation accomplished through a retro-Claisen activation of a nascent allylic alcohol following an initial …
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Photoassisted Synthesis of Complex Polyheterocycles via Rational Design of Tailored Photoprecursors
… classical elimination of the scaffold and decarboxylative elimination. Through this base-catalyzed modification, we were able to access flat, aromatic, and complex heterocycles.</p> <p>With underutilization of photochemistry and the need of aromatic polyheterocycles, we tailored …
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Mass Spectrometric Analysis of Tyrosine Metabolic Enzymes
… use dopachrome as a substrate. DCE catalyzes a decarboxylative structural rearrangement of dopachrome to 5,6-dihydroxyindole (DHI), whereas DCT mediates the isomerization/tautomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA). DHI is oxidized easily, leading to the …
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Photoredox activation of SF₆ for fluorination, on-demand automated titration of organometallic reagents in continuous flow, and progress toward an enantioselective synthesis of bedaquiline
… and assessed for feasibility. Although decarboxylative arylation, hydrogen atom-transfer, and sulfur-ylide epoxidation proved ineffective for the in these routes, our latest efforts are focused on a much more precedented asymmetric epoxidation which will be the subject of future work. …
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Effiziente Methoden zur chemo enzymatischen Synthese von komplexen N-Glycanen des bisecting Typs
… das Glycosylhydroxylamin selektiv über eine decarboxylative Kondensation an ein Aminosäurederivat gebunden werden.
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Design and Application of Nanostructured Flavin Photocatalysts
… such as benzylic oxidations, sulfoxidations, decarboxylative transformations, isomerisations and [2+2] cycloadditions to name a few. It has been shown that flavin photocatalysts can be tuned to a specific application either through chemical structure modification or by the design of advanced …
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