Global ETD Search
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Showing 1 to 7 of 7 for “"Decapentaplegic (Dpp)"”.
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The role of Decapentaplegic (Dpp) in Drosophila wing development
Decapentaplegic (Dpp), a member of the TGF-[Beta] superfamily, acts as a morphogen to direct cell differentiation, determine cell fate and promote cell survival and proliferation in Drosophila wing development. To investigate the role of Dpp in Drosophila wing development, three aspects of the …
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Promoter Specificity Mediates the Independent Regulation of Neighboring Genes
… have studied three neighboring Drosophila genes: decapentaplegic (dpp), SLY1 homologous (Slh) and out at first (oaf). Several dpp enhancers are positioned close to Slh and oaf and yet these genes are unaffected by the dpp elements. However, when a transposon is located within the oaf gene, the dpp …
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Isolation, characterization, and transcriptional autonomy of theout at first gene of Drosophila melanogaster
… unit 3$\sp\prime$ of the enhancer rich decapentaplegic (dpp) disk region might remain transcriptionally autonomous of disk region influence, I isolated and characterized the out at first gene (oaf, previously named l(2)ND1), the first transcription unit 3$\sp\prime$ of the disk region. I …
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Role of endocytic trafficking during Dpp gradient formation
… in Drosophila demonstrated that the morphogen Decapentaplegic (Dpp) forms activity gradients by inducing the expression of several target genes above distinct concentration thresholds at different distances from the source. This way, Dpp contributes to developmental fates in the target field …
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The role of the wingless gene in the control of growth and pattern formation during drosophila wing development
… of the organizers have been identified. Thus Decapentaplegic (Dpp, a secreted signalling molecule of the TGF-B family) is the mediator of the A/P organizer, while Wingless (DWnt-l, a secreted molecule of the Wnt family) is a key mediator of the D/V organizer. In this thesis, several aspects of …
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Formation of morphogen gradients
… transport, recent experiments on the morphogen Decapentaplegic (Dpp) in the fruit fly Drosophila provide evidence for the importance of a cellular transport mechanism that was termed "planar transcytosis". In this mechanism, morphogens are transported through cells by repeated rounds …
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Morphogenetic signaling in growing tissues
… we find that the transport of the morphogen Dpp is mainly intracellular. We moreover show that the decay length of the Dpp gradient increases during development as a result of changing degradation rate and diffusion coefficient, whereas the drift of molecules due to growth is negligible. Thus …