Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Decapentaplegic"”.
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The role of Decapentaplegic (Dpp) in Drosophila wing development
Decapentaplegic (Dpp), a member of the TGF-[Beta] superfamily, acts as a morphogen to direct cell differentiation, determine cell fate and promote cell survival and proliferation in Drosophila wing development. To investigate the role of Dpp in Drosophila wing development, three aspects of the …
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Functional and developmental characterisation of matrix binding sites in decapentaplegic
In the last years it became evident that many cytokines do not only bind to their specific cell surface receptors but also interact with components of the extracellular matrix. Mainly in Drosophila, several enzymes were identified, that are involved in glycosaminoglycan synthesis. Mutations in …
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Promoter Specificity Mediates the Independent Regulation of Neighboring Genes
… have studied three neighboring Drosophila genes: decapentaplegic (dpp), SLY1 homologous (Slh) and out at first (oaf). Several dpp enhancers are positioned close to Slh and oaf and yet these genes are unaffected by the dpp elements. However, when a transposon is located within the oaf gene, the dpp …
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Isolation, characterization, and transcriptional autonomy of theout at first gene of Drosophila melanogaster
… unit 3$\sp\prime$ of the enhancer rich decapentaplegic (dpp) disk region might remain transcriptionally autonomous of disk region influence, I isolated and characterized the out at first gene (oaf, previously named l(2)ND1), the first transcription unit 3$\sp\prime$ of the disk region. I …
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Role of endocytic trafficking during Dpp gradient formation
… in Drosophila demonstrated that the morphogen Decapentaplegic (Dpp) forms activity gradients by inducing the expression of several target genes above distinct concentration thresholds at different distances from the source. This way, Dpp contributes to developmental fates in the target field …
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The role of the wingless gene in the control of growth and pattern formation during drosophila wing development
… of the organizers have been identified. Thus Decapentaplegic (Dpp, a secreted signalling molecule of the TGF-B family) is the mediator of the A/P organizer, while Wingless (DWnt-l, a secreted molecule of the Wnt family) is a key mediator of the D/V organizer. In this thesis, several aspects of …
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Formation of morphogen gradients
… transport, recent experiments on the morphogen Decapentaplegic (Dpp) in the fruit fly Drosophila provide evidence for the importance of a cellular transport mechanism that was termed "planar transcytosis". In this mechanism, morphogens are transported through cells by repeated rounds …
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Systemic and local signalling regulating neural stem cell proliferation
… conditions. I discovered upregulation of *dpp (decapentaplegic)*, a transforming growth factor (TGFβ) secreted morphogen, after feeding. Knockdown of Dpp in the fat body severely impaired NSC reactivation. Similarly, knocking down a key receptor for Dpp, Tkv (Thickveins), in the BBB glia led to …
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Deconvoluting genetic variants associated with aortic disease using stem cell models
… (MYLK, 123401069 ACT>A) and mothers against decapentaplegic homolog 4 (SMAD4, 51076665 C>T) were selected. CRISPR-Cas9 genetic editing introduced these mutations into wild type iPSC lines. The mutant lines were differentiated into vascular smooth muscle cells (VSMC), analysed with a …
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Morphogenetic signaling in growing tissues
During the development of multicellular organisms, organs grow to well-defined shapes and sizes. The proper size and patterning of tissues are ensured by signaling molecules as e.g. morphogens. Secreted from a restricted source, morphogens spread into the adjacent target tissue where they form a …
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Appendage development and early Distal-less regulation in arthropods: A study of the chelicerate Tetranychus urticae (Acarida)
A major goal of evolutionary developmental biology is to explore mechanisms and events underlying evolution of the myriad body plan morphologies expressed both genetically and phenotypically within the animal kingdom. Arthropods exhibit an astounding array of morphological diversity both within and …