Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Death Receptor 5"”.
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… drugs such as 5-FU are thought to trigger cell death via the intrinsic apoptosis pathway which involves caspase-9 activation as one of the initiating molecular events. However, our group recently found the new apoptotic pathways which are involved in 5-FU-induced apoptosisin which caspase-8 is …
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Development of novel antibody-targeted nanoparticle strategies for treatment of pancreatic cancer
… the TNF-related apoptosisinducing ligand (TRAIL) receptor 2/ death receptor-5 (DR5) pathway using the monoclonal antibody conatumumab (AMG 655). However, the results of these clinical trials proved disappointing with no survival advantage being observed. Subsequent literature has suggested that …
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Development of versatile drug delivery strategies using PLGA nanoparticles
… of NP covalently conjugated with anti Death Receptor 5 (DR5) monoclonal antibodies (mAbs) to target DR5 expressed on the surface of colorectal tumor cells. Anti DR5 mAbs conjugated NP demonstrated specific targeting and internalisation to colorectal carcinoma HCT116 cells, but more …