Global ETD Search
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Showing 1 to 4 of 4 for “"Dearomative functionalization"”.
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Arenophile-mediated dearomative functionalization of unactivated arenes
Two photomediated dearomative methods are reported using an “arenophile” called MTAD. Arene-arenophile cycloadducts are formed by irradiation of mixtures of unactivated arenes and MTAD at cryogenic temperatures with visible light. These cycloadducts are subsequently used as substrates in …
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Dearomative functionalization of simple arenes: Reduction and palladium-catalyzed syn-1,4-aminofunctionalizations
… Accordingly, many unique and enabling dearomative transformations have been developed and applied to the total synthesis of complex bioactive compounds. However, a significant challenge remains to be addressed in this field. That is, simple and non-activated arenes, such as benzene and …
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Dearomative transformations in synthesis: I. Dearomative dihydroxylation with arenophiles II. Total synthesis of lycoricidine and narciclasine III. Towards the total synthesis of collybolide
… particular, there is a paucity of reactions for dearomative installation of functionality into simple arenes in a selective and mild fashion. The first chapter of this dissertation describes the development of a dearomative functionalization reaction developed by our laboratory for the regio- and …
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Dearomative reduction of arenes through the use of arenophiles & studies towards the synthesis of cardiotonic steroids calotropin and calactin
A novel method for the dearomative reduction of arenes through the use of N,N-arenophile, MTAD, was developed. Cheap feedstock arenes undergo photocycloaddition with MTAD, and the cycloadduct can be treated further to furnish novel 1,3-cyclohexadienes or 1,4-diamino-2- cyclohexenes. The utility of …