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Showing 1 to 17 of 17 for “"Dealkylation"”.
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SYNTHESES AND ESTROGENICITY STUDY OF DIETHYLSTILBESTROL AND BISPHENOL-A ANALOGS AS POTENTIAL REPLACEMENT FOR BISPHENOL-A AND INVESTIGATION ON NOVEL REACTIONS INDUCED BY IODANE/QUATERNARY AMMONIUM HALIDES
… to explore aromatic bromination, N-nitrosation-dealkylation, and benzoate ester formation from benzylamines. Koser's reagent was found to be a suitable iodane for aromatic bromination reaction, whereas for N-nitrosation-dealkylation, IBX gave the best yields. Further, for …
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Steady State and Theoretical Investigations of Peptidylglycine α-Amidating Monooxygenase (PAM)
… PAM has previously been found to perform N-dealkylation, as well as O-dealkylation. We report here that a novel chemistry for PAM, S-dealkylation, has now been shown. PAM was able to catalyzes the hydroxylation and subsequent dealkylation for a series of substituted 2- (phenylthio)acetic …
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Mechanistic Studies of Peptidylglycine Alpha-Amidating Monooxygenase (PAM)
… imino-oxy acetic acid undergoes non-enzymatic O-dealkylation to the corresponding oxime and glyoxylate products. This phenomena was further studied using QM/MM methodology using different Cu/O species to determine which best facilitated the dealkylation event. It was determined that radical …
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Effects of Pycnogenol on Microsomal Cytochrome P450 Activity and Apoptosis
… P450 enzymes (GYP). A second study looked at O-dealkylation of the substrates benzyloxyresorufin (BROD), ethoxyresorufin (EROD) and methoxyresorufin (MROD) linked to CYP2B1,2C6 and 1A2, respectively. Pycnogenol significantly inhibited BROD, EROD and MROD activity in 6 mo and 20 mo liver …
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The Origin of Polycyclic Aromatic Hydrocarbons in Diesel Exhaust Emissions
… be accounted for by comparatively low rates of dealkylation of alkyl-substituted derivatives present in diesel fuel. The importance of dealkylation reactions during diesel combustion, was investigated by combusting a low aromatic fuel spiked with a non-radiolabelled alkyl-PAH, 2- and …
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Oxidation of Transition Metal Complexes with 3,7-Diazabicyclo[3.3.1]nonane-Derived Ligands
… the reaction mixture, provided evidence on the dealkylation at the tertiary amine donor N7 in the ligand (Figure 1.3) Further details about the possible steps of the oxidative N-dealkylation were obtained from DFT calculations. From the results a mechanism was postulated (Figure 1.4). Moreover, …
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Transfer of alkyl groups in novel amidine dications and other superelectrophiles
… superelectrophilic amidinium disalt V from which dealkylation takes place. The unprecedented α-aminotriflate IV was characterised by lowtemperature 1H- and 13C-NMR spectra and the rate of alkyl transfer for substrates III and VII determined. Unlike formamides III and VII, in silico and …
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
… IQ, MelQx, Trp-P-2, Glu-P-2 and PhIP and on the dealkylation of ethoxyresorufin (EROD) and methoxyresorufin (MROD) were investigated. All four isothiocyanates significantly inhibited the oxidation of NNK by hamster liver microsome. The isothiocyanates enhanced the reduction of NNK by hamster …
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Spectroscopic Studies of Some Semiquinone Radical Ions
… cation under certain conditions undergoes dealkylation to give secondary radicals. Anions of some alkylated 4,4'-biphenosemiquinones were prepared by the air oxidation of the diols in a variety of solvent mixtures and studied by ESR. The solvent dependance of the hyperfine coupling …
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Hydrolysis and Atmospheric Oxidation Reactions of Perfluorinated Carboxylic Acid Precursors
… mechanism was proposed involving an initial N-dealkylation step followed by loss of isocyanic acid to give a perfluorinated radical. The perfluorinated radical then produces PFCAs by a series of known atmospheric reactions. Finally, the biological hydrolysis of the polyfluoroalkyl phosphate …
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A Comparative In Vitro Metabolic Study of Certain Pesticidal Phenyl N-Methyl-Carbamates
… metabolism.</p> <p>These data indicate that N-dealkylation is the major route of metabolism for Zectran in all three species. Minor pathways included hydroxylation of the carbamate moiety N-methyl groups. Sulfoxidation and hydroxylation were the major routes of metabolism with Mesurol in all …
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Expanding the Role of Oxidoreductases in Benzylisoquinoline Alkaloid Metabolism in Opium Poppy
… respectively, showed novel and efficient O-dealkylation activities, including regioand substrate-specific O-demethylation and O,O-demethylenation. Preferred substrates for O,Odemethylenation by CODM and PODA were protopine alkaloids that serve as intermediates in the biosynthesis of …
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Syntheses, properties, and reactions of transition metal complexes of di(tert-butyl)amide and 2,2,6,6-tetramethylpiperidide
… equivalents of Li(tmp) induces ring-opening dealkylation of one tmp ligand and formation of a 1,1,5-trimethyl-5-hexenylimido ligand. A similar reaction is known for the di(tert-butyl)amido ligand. IR spectroscopic studies demonstrate that the tmp ligand undergoes ring-opening dealkylation at …
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Synthesis, characterization and chemical vapor deposition of transition metal di(tert-butyl)amido compounds
… compound Ti₂[μ-N(t-Bu)]₂Cl₂[N(t-Bu)₂]₂ via a dealkylation reaction. Rotation around the bis(tert-butyl)amido groups is hindered, with activation parameters of ΔH‡ = 12.8 ± 0.6 kcal mol-1 and ΔS‡ = -8 ± 2 cal K-1 ·mol-1, as evidenced by variable temperature 1H NMR spectroscopy. Treatment of …
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Physicochemical, biological and β-haematin inhibiting activity of pyrido-dibemequines, pyrido[1,2-α]benzimidazoles and their derivatives
… susceptibility to microsomal metabolism, with N-dealkylation identified as the main biotransformation route. The pDBQ metabolites exhibited solubility and membrane permeability profiles similar to the parent compounds at pH 6.5, albeit with reduced lipophilicity (cLogP range: 2.3 - 3.5). Their βH …
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Chemical approaches to the improved performance of nanoelectronic devices
… be due to a thermosalience transition or to an N-dealkylation process.