Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 76 for “"Deacetylases"”.
-
Roles of Class II Histone Deacetylases in the Cardiovascular System
… histone acetyltransferases (HATs) and histone deacetylases (HDACs), represents one of the fundamental mechanisms to control gene transcription. Class II histone deacetylases regulate developmental and physiological processes through interaction with and repression of a variety of transcription …
-
Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
<p>The inhibitors of histone deacetylases (HDACs) have shown promising neuroprotective and neuroactive properties. A set of pan- and isoform-specific HDAC inhibitors were evaluated for neurotrophic activity on Neuroscreen-1 (NS-1) cells, a subclone of PC-12 (rat pheochromocytoma) cells. </p> <p>The …
-
Modulation of Histone Deacetylases Attenuates the Pathogenesis of Alzheimer's disease
ZusammenfassungWir haben noch nicht gelernt, wie wir lernen. Die molekularen und physiologischen Mechanismen, die den Prozess der Kognition steuern, sind immer noch ein Rätsel. Dies schränkt uns auch stark in unserer Fähigkeit ein, den kognitiven Erkrankungen entgegenzuwirken. Angesichts einer …
-
Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… interact with histone acetyltransferases and deacetylases. We show that histone deacetylase inhibitors efficiently block adipocyte differentiation in vitro. Furthermore, through a loss-of-function approach, we provide evidence that histone deacetylases 1 and 2 play redundant and requisite …
-
Targeting Histone Deacetylases (Hdac) For The Treatment of Soft Tissue Sarcoma
<p><strong>Targeting Histone deacetylases (HDAC) for the </strong><strong>treatment of genetically complex soft tissue sarcoma</strong></p> <p>Histone deactylase inhibitors (HDACi) are a new class of anticancer therapeutics; however, little is known about HDACi or the individual contribution of …
-
The Role of Class I Histone Deacetylases in Cardiovascular Development and Disease
… of histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDAC inhibitors continue to show promise in a multitude of pathological settings such as cancer and heart disease, however the role of individual HDACs remains largely unexplored. Genetic studies have shown class II HDACs …
-
The Role of Histone Deacetylases in Cytokine Regulation in Human Gestational Tissues
… leading to further studies into how histone deacetylases may be involved in cytokine regulation. However, despite the importance of appropriate histone deacetylase activity during development little is known about histone deacetylases (HDACs) in the placenta and membranes. The overall aim of …
-
Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability
<p>Breast cancer is the most common malignancy diagnosed in women. 15-20% of these cancers overexpress the HER2 (ERRB2) oncoprotein. HER2-positive breast cancers are generally aggressive and are associated with poor prognosis. Unfortunately, only a mere 30% of HER2-positve patients respond to …
-
Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… binding domain proteins (MBDs) and histone deacetylases (HDACs), is essential for mammalian development, with the nervous system demonstrating particular sensitivity to perturbations. Little is known, however, about the role of DNA methylation in the stage-specific differentiation of …
-
Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1
… fission yeast to study the roles of the histone deacetylases (HDACs) Sir2 and Clr3 in heterochromatin formation and cancer associated mutations of the DEAD-box RNA helicase DDX3X, homolog of fission yeast Ded1, in translational control. Heterochromatin in fission yeast is characterized by …
-
Molecular and Genetic Analysis of Novel Epigenetic Silencing Factors Dhp1, Lsd1, and Lsd2
… Rix1 complex member Ipi1, and histone deacetylases Lsd1 and Lsd2. We are however able to identify previously unreported genetic interactions between SPAC25G10.01Δ and mutants of histone deacetylases Clr3 and Sir2. We also generate novel lsd1 and lsd2 mutants for these analyses, which …
-
N⁶-formylation of lysine : a pathological secondary modification of proteins
… in cells, our investigation of histone deacetylases revealed that despite chemical similarity of N⁶-formyllysine to N⁶-acetyllysine, the former is refractory to removal by histone deacetylases, which suggests that they will persist throughout the life of individual histone proteins. If …
-
Strategies for targeting cancer: small molecules, epigenetics and drug design
… recent status of drugs developed using histone deacetylases (HDAC) and histone deacetylases inhibitors (HDACi) for targeting specific cancers. And in my final chapter of SET-domain proteins, my research focused on comparing the methyltransferase activity inhibition of SMYD3 in two different …
-
Hdac3 is a Critical Regulator of Neural Crest Progenitor Cell Biology
… for normal development to occur. Class I histone deacetylases (Hdacs), including Hdac3, play critical roles in regulating gene transcription, through both epigenetic and non-epigenetic means. In this dissertation, I use mouse genetics to explore the previously undescribed role of Hdac3 in …
-
Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… I characterize the functions of two lysine deacetylases, SIRT1 and HDAC1, in the neuronal response to DNA double strand breaks (DSBs). Both SIRT1 and HDAC1 were previously shown to promote neuronal survival in a mouse model of neurodegeneration in which the appearance of DSBs precedes other …
-
Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… with Gsc which in turn recruits histone deacetylases to negatively regulate Mixl1 expression during early mouse development. Post-translational modification of transcription factors by SUMO proteins represents an important mechanism through which their activity is controlled. Here, I also …
-
Dissecting the Multifaceted Relationship Between Maize and Cochliobolus carbonum race 1
… utilizes HC-toxin, an inhibitor of histone deacetylases, as a key determinant of virulence. The maize Hm1 gene confers complete resistance to CCR1 at all stages of development by encoding for an NADPH-dependent reductase that inactivates HC-toxin. Hm1A, Hm1-SM1, and Hm1-SM2 are alleles of …
-
Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
Histone deacetylases (HDACs) are important regulators of developmental processes and cellular functions. However, their role in hematopoiesis has not been determined, and in Xenopus laevis, a specific function for HDACs has yet to be identified. In the present work, we employed the class I …
Page 1 of 4