Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"DeSUMOylation"”.
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… metabolism. These hearts also showed increased deSUMOylation of mitochondrial proteins including dynamin related protein (Drp1), which leads to nuclear translocation of mitochondrial apoptosis inducing factor (AIF). This induces massive loss of cardiomyocytes via caspase-independent apoptotic …
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Sumoylation of RNA Polymerase II Regulates Transcription in Saccharomyces cerevisiae
… of Rpb1, rather than merely as an instrument for desumoylation, which is an unexpected finding. Moreover, while impairing Rpb1 sumoylation at its major sumoylation site, K1487, has no apparent effect on growth, nascent transcription analysis from Global Run-on Sequencing (GROseq) reveals that a …
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
… Nav1.7 currents. Increasing deSUMOylation with sentrin/SUMO-specific protease SENP1 or SENP2 in wildtype CRMP2-expressing CAD cells decreased Nav1.7 currents. Consistent with reduced current density, biotinylation revealed significant reduction in surface Nav1.7 levels of CAD …
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Investigating the Role of Human Cytomegalovirus Protein LUNA in Regulating Viral Gene Expression during Latency
… thus raising the possibility that inhibition of deSUMOylation may serve as a novel therapeutic strategy to target latent HCMV infection.
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A STRUCTURAL AND FUNCTIONAL ATLAS OF THE HUMAN RIXOSOME COMPLEX
… with novel functional data on the rixosomal deSUMOylation enzyme SENP3; 3) the cryo-EM structure of the rixosomal RNA processing module RNase PNK and the characterization of a rixosome binding domain that mediates the module’s integration. In addition to the data in these formal results …
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Applications of Ion Mobility Mass Spectrometry - Screening for SUMOylation and Other Post-Translational Modifications
… is known about the processes of SUMOylation and deSUMOylation, exactly how it mediates its various functions and 4 different human isoforms remains unclear. This is due in part to the extremely low abundance of modified proteins (about 2% of a given substrate will become modified), and the large …