Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"De novo proteins"”.
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Using the Marcus Inverted Region and Artificial Cofactors to Create a Charge Separated State in <i>De Novo</i> Designed Proteins
<p>To create an efficient de novo photosynthetic protein it is important to create long lived charge separated states. Achieving stable charge separation leads to an increase in the efficiency of the photosynthetic reaction which in turn leads to higher yields of end products, such as biofuels, …
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De novo designed protein switches to enable increased specificity of targeted therapeutics
… their specificity is limited and prone to incidentally harming healthy cells. This is problematic for developing treatments for solid tumors where ‘tumor-specific’ antigens are also expressed on healthy tissues. Using computational protein design, we developed colocalization- dependent switches …
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Biomimetic Surface Coatings from Modular Amphiphilic Proteins
… cell behavior. In this thesis, a series of de novo proteins for bio-functionalization of interfaces was designed, synthesized, and studied. These proteins are based on a diblock motif consisting of a surface-active, amphiphilic block β-sheet domain linked to a disordered, water-soluble block …
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On the Origins of Genetic Novelty in Drosophila
… be variation without a source of new variants. Understanding how novelty emerges, then, is a crucial problem of basic relevance in evolutionary biology. In this thesis, I examine two aspects regarding the origins of novelty: first, how new proteins originate and subsequently evolve; second, how …
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Coordination Geometries in Metallobundles Enforcing Oxidative and Hydrolytic Catalysis and Designing Biomaterials for Use As Antimicrobials
<p>De novo protein design permits discovery of intricate folds and functions emulating natural enzymes in simpler, yet robust model constructs. Helical bundles serve as premier scaffolds to incorporate diverse reactivities from oxidative, reductive, to hydrolytic transformations observed in much …
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De Novo Protein Structure Modeling from Cryoem Data Through a Dynamic Programming Algorithm in the Secondary Structure Topology Graph
<p>Proteins are the molecules carry out the vital functions and make more than the half of dry weight in every cell. Protein in nature folds into a unique and energetically favorable 3-Dimensional (3-D) structure which is critical and unique to its biological function. In contrast to other methods …
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Protein Engineering for Biomedical Materials
The inherent design freedom of protein engineering and recombinant protein production enables specific tailoring of protein structure, function, and properties. Two areas of research where protein engineering has allowed for many advances in biomedical materials include the design of novel protein …