Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"De novo lipogenesis"”.
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Dietary amino acids and their contribution to de novo lipogenesis
The alarming increase in the incidence of the metabolic syndrome is the result of the nutrition transition featuring dietary patterns high in sugars, particularly liquid carbohydrates in the form of sugary beverages, fat, and protein from red meat. The aim of this thesis was to investigate the …
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The Role of Akt2 in Hepatic Lipid Metabolism
… is the abnormal accumulation of triglycerides in the liver, called hepatic steatosis, though the underlying pathogenesis of this accumulation remains unclear. There is certainly an inappropriate increase in de novo lipogenesis in the livers of individuals with hepatic steatosis, but the …
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THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES
… Ezetimibe, by inhibiting NPC1L1 function, is widely used to lower blood cholesterol in humans. Recently, NPC1L1 deficiency or ezetimibe treatment has been shown to improve hepatic steatosis in rodents and humans without a defined mechanism. In the first project, we found that genetic …
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Effect of pregnancy on adipose tissue biology in a mouse model of obesity
… and baby. Obese mothers are more likely to develop gestational diabetes, hypertensive disorders including preeclampsia, thromboembolic complications, miscarriage, and have an increased need for induction of labour. Babies born from obese mothers can be abnormally large (macrosomia) or small …
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… mortalities. Significant advances have been made in breast cancer therapy to date. However, the development of targeted therapies remains essential to overcome the lack of treatment options for TNBCs and acquired resistance. Metabolic reprogramming, wherein cancer cells rewire their metabolism …
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New Analytical Methodologies at the Frontier of Cellular Lipidomics
… has experienced a growing interest worldwide, to the point that the term "lipidomics" was coined. This field is a subset of metabolomics, and the interesting point about these two sciences is that they are closest to the phenotype as compared to their "omics" counterparts (genomics, …
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Novel Roles of GLP-1 and GLP-2 in the Regulation of Hepatic Lipid/Lipoprotein Homeostasis and the Involvement of BAT Activation
… resistance and type 2 diabetes (T2D) include the development of non-alcoholic fatty liver disease (NAFLD) and an atherogenic fasting dyslipidemic profile, primarily due to increases in hepatic very low density lipoprotein (VLDL) production. Recent studies have implicated neuronal signalling …
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The Aging-Induced Decline in Beige Adipose Tissue Development
… and combat obesity. Aging has been shown to decrease the amount and function of beige adipose tissue, but the mechanism is incompletely understood. Beige adipose tissue develops in two ways: either through the de novo differentiation of adipocyte stem and progenitor cells (ASPCs), or the …
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Regulation of milk fat synthesis by dietary fatty acids
The objectives of this thesis research were to determine the molecular mechanisms by which dietary fatty acids (FA) regulate lipogenic gene expression and milk fat synthesis. Principal component and multivariate analyses were conducted to establish the relationship between milk fat and FA …
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The role of Ad-36 and its E4orf-1 protein in modulating glycemic control
… for Type 2 Diabetes Mellitus (T2DM) include a range of anti-diabetic drugs, supplemented by lifestyle modifications to reduce dietary fat intake and body fat. However, for their anti-diabetic action, most drugs recruit insulin signaling pathways, which are already impaired in T2DM. Also, …
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Pyruvate Cycling Pathways and Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells
… Intracellular glucose metabolism drives a cascade of events, including ATP production, calcium influx, and insulin processing, culminating in insulin granule exocytosis. However, insulin secretory mechanisms are incompletely understood. β-cells have the capacity to flow pyruvate into the TCA …
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
… apolipoproteins (apo) can impact triglyceride (TG) transport by modulating VLDL assembly and secretion. Here we explore the impact of apoA-IV on VLDL particle expansion. Previous studies demonstrated that apoA-IV expression promotes apoB lipoprotein-mediated TG secretion in transfected …
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Effect of Feeding Regimen and Age on Lipid Metabolism in Broiler Breeder Hens and Progeny
… A series of experiments were conducted to determine the effects of age and feeding programs on lipid metabolism in breeder hens and progeny. In the first trial, the rate of yolk absorption and fatty acid profiles in the yolk were compared among 28, 35, and 49wk old hens. The results …
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Investigating the impact of non-alcoholic fatty liver disease on the pathogenesis and progression of heart failure with preserved ejection fraction
… public health concern due to its increasing incidence alongside a lack of effective therapeutics. Understanding how this condition develops is therefore of the utmost importance in order to develop preventative strategies. As such, investigation of the cardiac functional effects of HFpEF risk …
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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. In this thesis, we elucidate the effects of hormones and nutrients on biological responses and regulatory mechanisms in pancreatic β-cells and adipocytes. The information is scarce with regard to …
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Effects of fescue toxicosis and chronic heat stress on murine hepatic gene expression
… coenophialum. Signs of fescue toxicosis include increased body temperature and respiration rate and decreased milk yield and reproductive performance. Laboratory mice also exhibit symptoms of fescue toxicosis as indicated by reduced growth rate and reproductive performance. Mice were used to …
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The mechanism behind LPA-mediated tumor cell growth and oncogenesis remains poorly understood. In this thesis project I used ovarian …