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Showing 1 to 7 of 7 for “"De novo genome assembly"”.
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Error Correction and de novo Genome Assembly of DNA Sequencing Data
The ability to obtain the genetic code of any species has caused a revolution in biological sciences. Current technologies are capable of sequencing short pieces of DNA with very high quality. These short pieces of DNA determint the sequence of bases in the genome of any species. This information …
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Computational Methods for Haplotype-aware De Novo Genome Assembly from Long Reads
Genomes of the same species usually show high diversity due to genetic variations. Most eukaryotes involve multiple copies of genomes, each of which is inherited from one of the ancestors. Whereas prokaryotes, such as virus and bacteria, are prone to form a collection of closely related strains …
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Towards cloning of a novel SCN resistance locus using de novo genome assembly and fosmid screening
… contains a resistance QTL to soybean cyst nematode (SCN) Heterodera glycines, a devastating pest of soybean. This resistance QTL has been fine mapped in PI 468916 to a distance of 147kb. Through the use of whole genome sequencing with de novo assembly we were able to gain information about the …
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Analysis of the effect of genetic heterogeneity on de novo genome assembly using Xylocopa virginica as a model.
… genomic and genetic research, and as a result, de novo genome sequencing and assembly for non-model organisms has now become a common task in genome research. However, the integral properties of a genome such as ploidy, mutations, and repeat content impose issues for current genome assemblers. …
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Improving genome assembly by identifying reliable sequencing data
De novo Genome assembly and k-mer frequency counting are two of the classical prob- lems of Bioinformatics. k-mer counting helps to identify genomic k-mers from sequenced reads which may then inform read correction or genome assembly. Genome assembly has two major subproblems: contig construction …
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Efficient Algorithms for Prokaryotic Whole Genome Assembly and Finishing
<p>De-novo genome assembly from DNA fragments is primarily based on sequence overlap information. In addition, mate-pair reads or paired-end reads provide linking information for joining gaps and bridging repeat regions. Genome assemblers in general assemble long contiguous sequences (contigs) …
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Tiger: tiled iterative genome assembler and approximate multi-genome aligner
Sequence assembly and alignments are two important stepping stones for comparative genomics. With the fast adoption of the next-generation sequencing (NGS) technologies and the coming of the third-generation sequencing (TGS) technologies, genomics has provided us with an unprecedented opportunity …