Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Dazl"”.
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Dazl regulates mouse embryonic germ cell development
… of the germ cellspecific RNA binding protein DAZL. The sufficiency for the absence of meiosis to drive male germ cell differentiation was then tested by examining non-meiotic XX germ cells in the Dazl-deficient ovary. These cells did not exhibit male differentiation indicating that the absence …
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A role for Dazl in commitment to gametogenic fate in embryonic germ cells of C57BL/6 mice
… change as well. Disruption of mouse Dazl, a member of a germ-cell-specific gene family found in many metazoans, causes infertility due to germ cell loss. However the nature and timing of germ cell loss has proven variable in the mixed background mice studied thus far, and the focus …
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The genomic and genetic basis of mammalian sexual reproduction : sequence of the mouse Y chromosome, and a gene regulatory program for meiotic prophase
… ovaries over time and space, and in mutants of Dazl and Stra8 - key genes required for meiotic initiation. We determined that genes are regulated in three classes. Class 1 genes are expressed independently of Stra8, class 2 genes are expressed partially independently of Stra8, and Class 3 genes …
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Using Xenopus laevis to study the mechanisms governing the early germline development and the formation of vertebrate body plan
… results reveal that Dzip1, by interacting with Dazl (Deleted in Azoospermia-like), controls the development of PGC in early embryos. Disrupting the physical interaction between Dzip1 and Dazl results in reduction of PGCs. Collectively, we defined the roles of Dzip1 on early germline development …
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Isolation, characterisation and in vitro potential of Oogonial stem cells
… liposomal-mediated transfection of cells with a DAZL overexpression plasmid to assess their meiosis-related gene response. Scarce populations of putative OSCs were retrieved from 5 human samples (aged 13- 40 years) and 6 bovine samples. The cells were cultured long-term for up to 7 months and …
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The human Deleted in Azoospermia gene family : structure, function and evolution
… boule by overexpression of human DAZ and mouse DAZL proteins in testes of boule deficient flies. This functional assay suggests some functional conservation of DAZ and boule function. This thesis uncovers the genomic complexity, dynamic instability and evolution of a Y chromosomal gene family …