Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Daxx"”.
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Functional Analysis of Daxx In Tumorigenesis of Pancreatic Neuroendocrine Tumors and Embryonic Development
<p>Death domain-associated protein 6 (Daxx) is a histone chaperone specific to Histone 3.3 (H3.3). DAXX interacts with ATRX forming a chromatin remodeling complex, which deposits H3.3 into telomeric and pericentric region of the genome. The importance of Daxx was manifested in embryonic …
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The role of DAXX in the selective autophagy receptor SQSTM1/p62 phase condensation
… it. Via an unbiased yeast two-hybrid screening, DAXX is found a p62 binding protein. Further experiments confirmed that cytoplasmic DAXX promotes p62 puncta formation and drives p62 liquid phase condensation. In vitro experiments also confirmed that DAXX promotes p62 phase condensation. Evidence …
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Dissecting Mammalian Replication-Independent Chromatin Assembly — Biochemical and Structural Studies on the H3.3-Specific Histone Chaperones Hira and Daxx
… able to single out the death-associated protein Daxx as an bona fide histone H3.3 chaperone. Furthermore, I show that Daxx cooperates with an ATP-dependent chromatin remodeler, ATRX, in depositing histone H3.3 at telomeres in vivo (Chapter 2). I show that an evolutionary conserved histone binding …
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Insights into the molecular mechanisms of function and regulation of histone crotonylation
… assays identified the histone chaperone DAXX, an important chromatin factor implicated in cancer processes, as a candidate crotonylated histone binder. Biochemical validations and characterisations of this interaction were performed in colon-derived epithelial cells, where knocking down …
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Charakterisierung zellulärer Interaktionsproteine des Nebenkapsidproteins L2 humaner Papillomviren
… Interaktion zu dem POD-lokalisierten Protein Daxx aufzuzeigen und die entsprechenden Interaktionsbereiche in der Sequenz von PLINP und Daxx durch Deletionsanalysen einzugrenzen. L2 kann dabei den Effekt der veränderten Lokalisation von PLINP bei einem Daxx-knockout teilweise revidieren. Eine …
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Genome-Wide Localization And Novel Deposition Pathways Of Histone Variant H3.3 In Embryonic Stem And Neuronal Precursor Cells
… spectrometry reveal that the proteins Atrx and Daxx associate with H3.3 in a Hira-independent manner. Using Atrxflox and Atrxnull mouse ES cells, I find that Atrx is specifically required for Hira-independent enrichment of H3.3 at telomeres and rDNA, and for repression of telomeric and ribosomal …
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The role of the histone variant H3.3 and its chaperones in the response to DNA damage
… distinct and specific chaperone complexes: ATRX/DAXX and HIRA. H3.3 and its chaperones have been implicated in the response to and repair of various types of DNA damage. Furthermore, a supply of H3.3 has been shown to be required to maintain replication fork progression in the transformed avian …
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Identifying genetic biomarkers for diagnosis of prostate cancer in South African men
… in the PCa group with p values <0.05; DAXX, EGFR, RASSF1, SOX4, and TIMP2, upregulated genes were ACACA, AR, CDKN2A, ERG and FASN but were also not statistically significant. The study shows similarly differentially expressed genes as seen in international studies. Of note PTEN, MKI67 …
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ST(ILL) SOUNDS: WAVES OF SOUND, HEALTH, AND THE CHOREOGRAPHIC PROCESS
st(ill) sounds: waves of sound, health, and the choreographic process, explores the intersections of sound, healthcare, choreography, and dance performance. The research draws upon psychology, physical and cognitive science, visual art, technology, linguistics, and cripistemologies. Central to the …