Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Daptomycin"”.
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Molecular Basis of Cell Membrane Adaption Against Daptomycin in Enterococcus faecalis
<p>Daptomycin is a last-resort lipopeptide antibiotic that disrupts cell membrane (CM) and peptidoglycan homeostasis (Grein et al., 2020a; Müller et al., 2016a). Enterococcus faecalis has developed a sophisticated mechanism to avoid daptomycin killing by redistributing CM anionic phospholipids away …
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Daptomycin versus Vancomycin for Empiric Treatment of Methicillin-Resistant S. aureus among Hospitalized Patients: An Institutional Cost-Breakpoint Analysis
… hospitalization days, costs, and mortality. Daptomycin was shown to be noninferior to vancomycin in a phase III clinical trial; however the study was limited by low rates of MRSA infection and before the emergence of strains with reduced susceptibility to vancomycin. Purpose: The purpose of …
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Total Synthesis of Naturally Occurring Antimicrobial Peptides
… chemical synthesis of the lipopeptide antibiotic daptomycin and analogues along with evaluation of their antibacterial activity. Tikitericin is a newly described lanthipeptide characterized by four intramolecular thioether linked (methyl)lanthionine bridges. It was isolated from the New Zealand …
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Modulating activity of vancomycin and daptomycin on the expression of gene involved in reduced glycopeptide susceptibility in Staphylococcus aureus
Negli ultimi dieci anni l'aumentato uso di vancomicina e teicoplanina (glicopeptidi), come antibiotici di prima linea nel trattamento di infezioni causate da Staphylococcus aureus meticillino-resistenti (Methicillin Resistant S.aureus-MRSA), ha portato all'insorgenza di ceppi con ridotta …
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Multiple gene contribution to the phenotypic and genotypic Daptomycin non-susceptible (DNS) variants of Methicillin-Resistant Staphylococcus aureus isogenic strains
Daptomicina (DAP), un lipopeptide ciclico, costituisce ad oggi una valida alternativa per il trattamento delle infezioni da Staphylococcus aureus multi-resistente (MDR) che non rispondono alla terapia con vancomicina. Case reports di fallimenti terapeutici associati a ridotta sensibilità a DAP …
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A retrospective study to evaluate the efficacy of trimethoprim/sulfamethoxazole (TMP/SMX) compared to daptomycin or linezolid for the treatment of infections due to methicillin-resistant <i>staphylococcus aureus</i> (MRSA)
… challenge. Main therapeutic options include Daptomycin and Linezolid, two new, expensive drugs, and trimethoprim/sulfamethoxazole(TMP/SMX), an old, inexpensive agent. Study aims were to compare the clinical efficacy and potential cost savings associated with TMP/SMX use.</p> <p>Methods: A …
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Two strategies to deepen knowledge the antibiotic resistance related traits in Italian MDR Staphylococci: comparative transcriptomic of two DAP-R/DAP-S MRSA isogenic couples and CRISPR system characterization of pathogenic S. epidermidis
… of Staphylococcal mRNAs and small-RNAs in daptomycin resistance, with multiple pathways associated, including the cell-wall biosynthesis and organization, metabolism, nucleic acid metabolism, stress response and transport, confirming the role of transcriptome in developing antibiotic …
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Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
… resistance to cell membrane (CM) stressors like daptomycin (DAP), a front-line drug for multi-drug resistant infections. DAP resistance (DAP-R) in <em>E. faecalis </em>is mediated by CM phospholipid alterations. Emergence of DAP-R often leads to b-lactam resensitization, a phenomenon called the …
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Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… no previously known antiviral activity (e.g., daptomycin) were identified as inhibitors of ZIKV infection. Several drugs reduced ZIKV infection across multiple cell types.</p><p>We propose that the EMC may be exploited as a novel therapeutic target for multiple flaviviruses in the future. Also …
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ST-1 VISA/DAP-R CA-MRSA INTEGRATED OMICS: A FIRST REPORT OF HYPER-VIRULENCE AND MULTI-DRUG RESISTANT SUPERBUG
… in rpoB related to rifampicin/vancomycin and daptomycin resistance, respectively. The Resistome of the strain-pair was characterized by the presence of genes involved in aminoglycosides, β-lactams, macrolides and tetracyclines resistance, reflecting a multi-drug resistant behaviour. While the …
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Eluding Antibiotic Resistance: Capitalizing On Antimicrobial Peptides Interaction With The Lipid Bilayer
… the Food and Drug Administration approved Daptomycin (DAP) in 2003 for treatment of severe skin infections caused by susceptible Gram-positive organisms. Currently, there are 12 to 15 examples of modified natural and synthetic AMPs in clinical development. But most of these agents are …
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Enumeration, isolation, identification and probiotic characterisation of lactic acid bacteria from Nigerian human breast milk
… and quinupristin/dalfopristin and resistant to daptomycin. Most of the LAB were resistant to erythromycin, gentamicin tetracycline and vancomycin. Antimicrobial resistance genes for erythromycin and tetracycline were confirmed for three LAB.
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Chemical Synthesis of Novel Calcium-Dependent Lipopeptide Antibiotics
… lipopeptide antibiotics (CDLAs) of which daptomycin is the only novel antibiotic introduced for clinical use in the last 20 years. Recently, metagenomic mining emerged as a novel platform for discovery of clinically relevant natural products delivering two examples of novel sub-classes of …
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Διερεύνηση λοιμώξεων από πηκτάση-αρνητικά στελέχη του γένους Staphylococcus σε ασθενείς με προσθετικά υλικά
… teicoplanin, vancomycin, linezolid και daptomycin, ενώ μόνο τέσσερα στελέχη ήταν πολυανθεκτικά. Οι S. lugdunensis της συλλογής μας έδειξαν μικρή γενετική ποικιλομορφία. Τα 38 στελέχη ταξινομήθηκαν σε επτά κλώνους, με δύο κύριους PFGE τύπους (C και D), οι οποίοι περιελάμβαναν 22 και εννέα …