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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 23 for “"Damage-associated molecular patterns"”.

  1. Mitochondrial damage-associated molecular patterns (DAMPs) in inflammatory bowel disease

    Boyapati, Ray KiranThe University of Edinburgh2018

    … have yet to be thoroughly investigated in IBD is damage-associated molecular patterns (DAMPs) including mitochondrial DNA (mtDNA). It has been recently shown that gut mitochondrial dysfunction can result in loss of epithelial barrier function and the development of colitis. Mitochondrial DAMPs …

    edinburgh Repository record

  2. Toll-like receptor mediated responses to adsorbed damage-associated molecular patterns on biomaterial surfaces

    McKiel, Laura2020

    … interactions is not well understood. Damage-associated molecular patterns (DAMPs) are endogenous ligands released by stressed or damaged tissues to stimulate sterile inflammatory responses via Toll-like receptors (TLRs) and other pattern recognition receptors. The work in this thesis …

    queens Repository record

  3. Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells

    전, 새봄2012

    … system is programmed to recognize series of molecular patterns, pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). PAMPs are presented by microorganisms, whereas DAMPs include endogenous intracellular molecules released by activated or necrotic …

    ajou Repository record

  4. Investigating The Effect Of Chronic Muscle Use And Disuse On Innate Immune Signaling In Skeletal Muscle

    Khemraj, Priyanka2025

    … complex, by augmenting the response against damage-associated molecular patterns (DAMPs). The objective of this study was to investigate how various metabolic conditions affect innate immune activation and mitochondrial health within skeletal muscle, which has not been fully elucidated. To …

    york Repository record

  5. The role of PLK1 in NLRP3 inflammasome activation

    Baldrighi, MartaUniversity of Cambridge2020

    … assembles in response to a variety of DAMPs (Damage-Associated Molecular Patterns) and PAMPs (Pathogen-Associated Molecular Patterns). Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokines (IL-1 and IL-18) release and pyroptosis, an inflammasome-specific form of cell death. …

    cambridge Repository record

  6. Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy

    Aghda, Niloofar HeshmatiTexas State University2020

    … and is characterized by the presentation of damage associated molecular patterns (DAMPs). NPs were made from biocompatible polymers, poly(lactic acid)-b-poly(ethylene glycol) and bovine serum albumin. Both NPs were loaded with doxorubicin, a chemotherapeutic agent, and indocyanine green, a …

    texas-state Repository record

  7. Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis

    Bergenfelz, CarolineDepartment of Laboratory Medicine, Lund University2014

    … cancerous cells. On the other hand, tumor-associated immune cells can contribute to tumor progression by secreting growth factors as well as immunosuppressive, pro-angiogenic and/or pro-metastatic mediators. In this thesis we identified a factor (Wnt5a) that may be involved in skewing …

    lund Repository record

  8. The role of mitochondrial DAMPs on the inflammatory response in an <i>in vitro</i> model of canine SIRS

    Friedenberg, Steven GeneThe Ohio State University2013

    … conditions.Endogenous danger signals from damaged cells trigger inflammatory responses in sepsis and conditions leading to SIRS. Much work has recently been performed that demonstrates the importance of signals from mitochondrial fragments – termed damage-associated molecular patterns or …

    ohiolink Repository record

  9. Inhibition of TLR4 minimizes islet damage due to sterile inflammation and improves islet transplant outcomes.

    Chang, Charles A., 1991-Baylor University.2018

    … mediator of sterile inflammation by sensing damage-associated molecular patterns (DAMPs) and compromising graft function, making it a putative therapeutic target. Here, we study the effects of TLR4 blockade during the peri-transplant period on islet transplant outcomes using TAK-242, a small …

    baylor Repository record

  10. Expression of inflammasome-related molecules from U87MG cells cocultured with Naegleria fowleri in the non-contact system

    심, 문희2013

    … detect and respond to a large range of pathogen-associated molecular patterns (PAMPs), including bacterial flagellin, and damage-associated molecular patterns (DAMPs), such as uric acid crystals. inflammasomes comprise a member of the NOD-like receptor (NLR) family, such as NLRP3 and IPAF, and …

    ajou Repository record

  11. The Role of Arabidopsis thaliana Cyclic Nucleotide-Gated Channels 2, 6, and 19 in Extracellular ATP Signalling

    Ning, YouzhengUniversity of Cambridge2023

    … development, salt tolerance, immunity, and the Damage-Associated Molecular Patterns (DAMP) response. Two plasma membrane (PM) eATP receptors DOES NOT RESPOND TO NUCLEOTIDES1 (DORN1/P2K1) and DORN2/P2K2 have been identified in Arabidopsis thaliana in the past decade. The perception of eATP leads …

    cambridge Repository record

  12. Investigating the ablative and immunomodulatory effects of high frequency irreversible electroporation on osteosarcoma in-vitro

    Patwardhan, Manali NitinVirginia Tech2024

    … ablates OS cells, induces the release of damage-associated molecular patterns (DAMPs), and promotes pro-inflammatory immune activating signatures in macrophages and T cells. Using an in-vitro model, my master's thesis focused on 1) Determining the electric field strength that completely …

    vt Repository record

  13. Modulating the Inflammatory Response of Macrophages on Biomaterial Surfaces

    Comas, Rosa2019

    … adsorb to the biomaterial surface, including damage-associated molecular patterns (DAMPs) that are released by cells upon necrosis or when under considerable amounts of stress. The immune response to implanted materials is carried out primarily by macrophages, which recognize DAMPs and other …

    queens Repository record

  14. The Molecular Mechanism of Platelet Activation in Inflammation

    Rashvand, ShaghayeghUniversity of Westminster2025

    … when released extracellularly, acting as damage-associated molecular patterns (DAMPs) that contribute to inflammation and thrombosis. This study investigates the role of extracellular histones in platelet activation, exploring their pro-thrombotic effects and the molecular pathways …

    westminster Repository record

  15. Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases

    Morrison, Holly AnnVirginia Tech2023

    … from pathogens via recognition of pathogen associated molecular patterns (PAMPs) to mount an immune response, as well as detecting damage associated molecular patterns (DAMP) to indicate an area of damage and signal tissue repair. The gastrointestinal tract is a major signaling hub for such …

    vt Repository record

  16. Mitochondrial dysfunction during ischaemia reperfusion injury in models of organ transplantation

    Gruszczyk, Anja VeronikaUniversity of Cambridge2020

    … for patients with severe and irreversible organ damage. Although the efficacy of transplantation has progressed immensely in recent years, one of the most damaging factors occurring during this surgical procedure, ischaemia reperfusion injury (IRI), is still a major contributor causing poor …

    cambridge Repository record

  17. The novel phosphorylation site PLCγ2 Y1217 facilitates the TREM2 amyloid-β sensing pathway in microglia

    Henderson, JamesUniversity of Cambridge2023

    … expressed on microglia and detects anionic damage associated molecular patterns such as phosphatidylserine and amyloid-β. In this study I aimed to identify differentially expressed genes (DEGs) in microglia isolated from the amyloidogenic TgCRND8 mouse line crossed with AD risk mutant TREM2 …

    cambridge Repository record

  18. Characterization of pro- and anti-inflammatory immune responses in SARS-CoV-2 infection

    Ivester, Hannah MarieVirginia Tech2024

    … response begins through recognition of pathogen-associated molecular patterns (PAMPs) from the virus, or from other signatures characteristic of tissue damage, damage-associated molecular patterns (DAMPs), by pattern recognition receptors (PRRs) that in turn stimulate pro-inflammatory signaling …

    vt Repository record

  19. The role of Toll-like receptors in Parkinson's disease

    Kennedy, CatherineUniversity of Cambridge2023

    … recognition receptors with the ability to detect damage-associated molecular patterns. The activation of TLRs, potentially occurring through the detection of aggregated α-synuclein, triggers the release of pro-inflammatory cytokines. This may result in chronic inflammation, which produces an …

    cambridge Repository record

  20. Investigating TLR-4 signalling in response to protein ligands

    Macleod, Charlotte VictoriaUniversity of Cambridge2018

    … receptor (PRR) that recognises the pathogen-associated molecular pattern (PAMP) lipopolysaccharide (LPS) produced by Gram-negative bacteria. LPS binds to Myeloid differentiation 2 (MD-2)/TLR-4 heterodimers, driving their dimerisation and inducing a conformational change of the intracellular …

    cambridge Repository record

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