Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Dabigatran"”.
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Use of direct oral anticoagulants in Scotland
… problems, the direct oral anticoagulants (DOAC) dabigatran, rivaroxaban, apixaban and edoxaban have been introduced. However, real-world information regarding the utilisation of DOACs as well as their clinical effectiveness and safety is still scarce. Hence, the aim of this project was to …
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FUNCTIONAL STUDIES WITH DIRECT ORAL ANTICOAGULANTS: INVESTIGATION OF THE REGULATION OF KEY BLOOD COAGULATION PROTEASES
… between the direct thrombin inhibitors dabigatran and argatroban yield divergent exosite-mediated thrombin binding to physiologic ligands like yA-fibrin, y'-fibrin, factor Va, and factor VIII, interactions that govern clot-mediated protection from AT inhibition, and the various functions …
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Designing Allosteric Inhibitors of Thrombin
… hirudin, argatroban and the recently approved dabigatran, aim to reduce thrombin activity. There are several binding domains on thrombin including the active site, anion-binding exosites I and II, and the sodium binding site. We hypothesized that thrombin may be better regulated through an …
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Shared Decision-Making to Improve Uptake of and Adherence with Oral Anticoagulation Therapy for Stroke Prevention in Patients with Atrial Fibrillation: Initial Clinical Evaluation of a Web-Based Patient Decision Aid
… lower stroke risk, those placed on warfarin and dabigatran, as well as patients with concomitant end-stage renal disease. Second, a pilot randomized clinical trial was conducted to evaluate the acceptability of a novel, evidence-based decision aid designed to support shared decision-making …