Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Dab1"”.
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Role of Reelin-Dab1 Signaling in the Neuritogenesis
… 2 (ApoER2), inducing tyrosine phosphorylation of Dab1, a cytoplasmic adaptor protein of receptors. The Reelin-Dab1 signaling is regulatory key to migration and positioning of neuronal cell during brain development. It also reported that Reelin-deficient mice (reeler) showed a significant decrease …
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Vergleichende Untersuchung des Reelinsignalweges bei Wildtyp- und Presenilin-1-Knockoutmäusen während der embryonalen Hirnentwicklung
… In dieser Arbeit wurde untersucht, ob der Reelin-Dab1-Signaltransduktionsweg ebenfalls beeinflusst ist. Dazu wurden die Veränderungen der cortikalen Reelin- und Dab1- Expression im Verlauf der Embryogenese (zum Zeitpunkt E14,5, E16,5 und E18,5) in Presenilin-1-Knockout- und Wildtypmäusen …
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Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
… the tyrosine phosphorylation of disabled1 (Dab1), an adaptor protein binding to cytoplasmic domain of reelin receptors. Mice lacking reelin, Dab1, or both VLDLR and ApoER2, show identical phenotype and provide strong evidence for the involvement of these proteins in the same signaling axis. …
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Regulatory Role of ApoE and Apoer2 in Synaptic Activity: A New Insight into Alzheimer's Disease
… AD. A synaptic ApoE receptor, Apoer2, activates Dab1 and Src family tyrosine kinases (SFKs) upon binding to the extracellular ligand Reelin. Here, we show that this Reelin-Apoer2-Dab1-SFKs signaling complex greatly enhances the tyrosine phosphorylation as well as the calcium conductance of NMDA …
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
… case. Genes involved in reelin/PI3K signaling (DAB1), RTK signaling (PTPRE), and arginine biosynthesis (ASS1 and ASL) were frequently deregulated by methylation in these tumours. The anti-growth and anti-migratory properties of DAB1 and PTPRE were demonstrated in vitro. Preliminary …
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Single-phase vs. Three-phase High Power High Frequency Transformers
… and three-phase Dual Active Bridge Converter (DAB1 and DAB3) topologies with single and three-phase isolating transformers are selected for the transformer comparison. Design optimization of power transformer has been studied and simplified models have been built for the single and three-phase …
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Targeting Ion Channels to Distal Dendrites
… in reeler mice. In vivo viral knockdown of dab1, the intracellular signaling partner of reelin, leads to loss of HCN1 and other distally enriched ion channels specifically from the distal dendrites, but does not alter ion channel composition of the proximal dendritic compartment. Viral …
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Sediment Deposition in the Deep Sea: from Seamounts to the Hadal Trenches
The deep-sea fauna is dependent on the delivery of nutrients from the overlying waters. As data/observations show, benthic fauna is supported under both oligotrophic oceanic conditions and at the greatest (hadal) depths. This can be explained by an additional food source originating from sediment …